Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50032461
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329618(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(2,3'-bip...)
Affinity DataIC50: 180nMAssay Description:Inhibition of PAR1-mediated aggregation of TRAP-stimulated human plateletMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329618(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(2,3'-bip...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329618(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(2,3'-bip...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329618(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(2,3'-bip...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329618(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(2,3'-bip...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50261110(Ethyl [(3aR,4aR,8aR,9aS)-9(S)-[(E)-2-[5-(3-fluorop...)
Affinity DataKi:  8nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329617(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(2-met...)
Affinity DataKi:  12nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329616(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(2-cya...)
Affinity DataKi:  15nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329618(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(2,3'-bip...)
Affinity DataKi:  19nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329621(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-1-methyl-9-((E)-2-...)
Affinity DataKi:  42nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329624(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-methox...)
Affinity DataKi:  49nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329625(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(furan...)
Affinity DataKi:  61nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329626(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-1-methyl-3-oxo-9-(...)
Affinity DataKi:  75nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329622(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-1-methyl-9-((E)-2-...)
Affinity DataKi:  144nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329619(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(3,3'-bip...)
Affinity DataKi:  240nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329620(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(3,4'-bip...)
Affinity DataKi:  250nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329623(ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-1-methyl-3-oxo-9-(...)
Affinity DataKi:  337nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed