Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 50032586
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331556(2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331558(N-(1-amino-1,2-dioxopentan-3-yl)-2-chloro-4-(pyrid...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331575(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331555(N-(1-(1H-pyrazol-3-ylamino)-1,2-dioxopentan-3-yl)-...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331574(2-chloro-N-(4-methyl-1-(1-methyl-1H-pyrazol-3-ylam...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331572(N-(4-(1H-pyrazol-3-ylamino)-3,4-dioxobutan-2-yl)-2...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331573(N-(4-amino-3,4-dioxobutan-2-yl)-2-chloro-4-(pyridi...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331570(2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331558(N-(1-amino-1,2-dioxopentan-3-yl)-2-chloro-4-(pyrid...)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331569(2-chloro-N-(4-(5-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 10.5nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331571(N-(4-amino-3,4-dioxobutan-2-yl)-2-chloro-4-ethoxy-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331574(2-chloro-N-(4-methyl-1-(1-methyl-1H-pyrazol-3-ylam...)
Affinity DataIC50: 11.5nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331555(N-(1-(1H-pyrazol-3-ylamino)-1,2-dioxopentan-3-yl)-...)
Affinity DataIC50: 11.7nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331556(2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 12.9nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331568(N-(4-(1H-pyrazol-3-ylamino)-3,4-dioxobutan-2-yl)-2...)
Affinity DataIC50: 14.1nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 16.6nMAssay Description:Inhibition of human cathepsin V by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331564(2-methyl-N-(1-oxobutan-2-yl)-3-(trifluoromethyl)be...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331553(2-chloro-N-(4-(methylamino)-3,4-dioxobutan-2-yl)-4...)
Affinity DataIC50: 19.5nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 20.9nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331569(2-chloro-N-(4-(5-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 26.3nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331555(N-(1-(1H-pyrazol-3-ylamino)-1,2-dioxopentan-3-yl)-...)
Affinity DataIC50: 29.5nMAssay Description:Inhibition of human cathepsin V by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331567(N-(4-amino-3,4-dioxobutan-2-yl)-2-chloro-3-(triflu...)
Affinity DataIC50: 30.9nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331562(2-chloro-N-(1-oxobutan-2-yl)-3-(trifluoromethyl)be...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331562(2-chloro-N-(1-oxobutan-2-yl)-3-(trifluoromethyl)be...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313461(4-propyl-6-(3-(trifluoromethyl)phenyl)pyrimidine-2...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331570(2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 33.1nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331563(2-fluoro-N-(1-oxobutan-2-yl)-3-(trifluoromethyl)be...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331556(2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 36.3nMAssay Description:Inhibition of human cathepsin V by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331573(N-(4-amino-3,4-dioxobutan-2-yl)-2-chloro-4-(pyridi...)
Affinity DataIC50: 37.2nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313461(4-propyl-6-(3-(trifluoromethyl)phenyl)pyrimidine-2...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331553(2-chloro-N-(4-(methylamino)-3,4-dioxobutan-2-yl)-4...)
Affinity DataIC50: 46.8nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331575(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 47.9nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331568(N-(4-(1H-pyrazol-3-ylamino)-3,4-dioxobutan-2-yl)-2...)
Affinity DataIC50: 51.3nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 78nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as Lip10 accumulation by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331572(N-(4-(1H-pyrazol-3-ylamino)-3,4-dioxobutan-2-yl)-2...)
Affinity DataIC50: 91.2nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331567(N-(4-amino-3,4-dioxobutan-2-yl)-2-chloro-3-(triflu...)
Affinity DataIC50: 107nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331566(2-chloro-N-(1-oxopropan-2-yl)-3-(trifluoromethyl)b...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 141nMAssay Description:Inhibition of human cathepsin L by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331571(N-(4-amino-3,4-dioxobutan-2-yl)-2-chloro-4-ethoxy-...)
Affinity DataIC50: 195nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331556(2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-...)
Affinity DataIC50: 479nMAssay Description:Inhibition of human cathepsin L by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331565(2-methoxy-N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b...)
Affinity DataIC50: 692nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331555(N-(1-(1H-pyrazol-3-ylamino)-1,2-dioxopentan-3-yl)-...)
Affinity DataIC50: 891nMAssay Description:Inhibition of human cathepsin L by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331561(N-(1-oxobutan-2-yl)-3-(trifluoromethyl)benzamide |...)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331553(2-chloro-N-(4-(methylamino)-3,4-dioxobutan-2-yl)-4...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of human cathepsin V by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331555(N-(1-(1H-pyrazol-3-ylamino)-1,2-dioxopentan-3-yl)-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as Lip10 accumulation by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331558(N-(1-amino-1,2-dioxopentan-3-yl)-2-chloro-4-(pyrid...)
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as Lip10 accumulation by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331557(2-chloro-N-(1-(1-methyl-1H-pyrazol-3-ylamino)-1,2-...)
Affinity DataIC50: 3.24E+3nMAssay Description:Inhibition of human cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331555(N-(1-(1H-pyrazol-3-ylamino)-1,2-dioxopentan-3-yl)-...)
Affinity DataIC50: 5.75E+3nMAssay Description:Inhibition of human cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331553(2-chloro-N-(4-(methylamino)-3,4-dioxobutan-2-yl)-4...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
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