Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 50032623
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332171((S)-2-(4-chlorophenyl)-4-(piperidin-3-ylamino)thie...)
Affinity DataIC50: 1nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332159((S)-2-(4-carbamoylphenyl)-4-(piperidin-3-ylamino)t...)
Affinity DataIC50: 1nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332163((S)-2-(4-(dimethylcarbamoyl)phenyl)-4-(piperidin-3...)
Affinity DataIC50: 1nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332131((S)-2-(3-acetamidophenyl)-4-(piperidin-3-ylamino)t...)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332156((S)-2-(benzofuran-2-yl)-4-(piperidin-3-ylamino)thi...)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332132((S)-2-(3-aminophenyl)-4-(piperidin-3-ylamino)thien...)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332172(5-(4-chlorophenyl)-N-cyclohexyl-2-ureidothiophene-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332150((S)-2-(4-(methylsulfonyl)phenyl)-4-(piperidin-3-yl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332134((S)-2-(3,4-difluorophenyl)-4-(piperidin-3-ylamino)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332142((S)-2-(3-(hydroxymethyl)phenyl)-4-(piperidin-3-yla...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332140((S)-2-(3-methoxyphenyl)-4-(piperidin-3-ylamino)thi...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332177((S)-4-(azepan-3-ylamino)-2-(4-chlorophenyl)thieno[...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332141((S)-2-(4-methoxyphenyl)-4-(piperidin-3-ylamino)thi...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332133((S)-4-(piperidin-3-ylamino)-2-(pyridin-4-yl)thieno...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332164((S)-2-(6-methoxypyridin-3-yl)-4-(piperidin-3-ylami...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332162((S)-4-(piperidin-3-ylamino)-2-(3-(pyrrolidin-1-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332173((S)-2-(4-chlorophenyl)-4-(piperidin-3-ylamino)thie...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332144((S)-2-(4-phenoxyphenyl)-4-(piperidin-3-ylamino)thi...)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332130((S)-2-(3-chlorophenyl)-4-(piperidin-3-ylamino)thie...)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332155((S)-2-(3-chloro-4-fluorophenyl)-4-(piperidin-3-yla...)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332143((S)-2-(benzo[b]thiophen-5-yl)-4-(piperidin-3-ylami...)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332136((S)-2-phenyl-4-(piperidin-3-ylamino)thieno[3,2-c]p...)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332152((S)-2-(4-fluorophenyl)-4-(piperidin-3-ylamino)thie...)
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332138((S)-2-(1H-indol-4-yl)-4-(piperidin-3-ylamino)thien...)
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332149((S)-4-(piperidin-3-ylamino)-2-(4-(trifluoromethyl)...)
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332135((S)-4-(piperidin-3-ylamino)-2-(pyridin-3-yl)thieno...)
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332160((S)-4-(piperidin-3-ylamino)-2-(quinolin-6-yl)thien...)
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332129((S)-2-(3,5-difluorophenyl)-4-(piperidin-3-ylamino)...)
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332151((S)-2-(3-cyanophenyl)-4-(piperidin-3-ylamino)thien...)
Affinity DataIC50: 7nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332121(2-(4-chlorophenyl)-4-(2-(methylamino)ethylamino)th...)
Affinity DataIC50: 7nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332161((S)-2-(1-methyl-1H-indol-5-yl)-4-(piperidin-3-ylam...)
Affinity DataIC50: 8nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332153((S)-4-(piperidin-3-ylamino)-2-(4-(trifluoromethoxy...)
Affinity DataIC50: 9nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332148((S)-2-(4-chloro-3-fluorophenyl)-4-(piperidin-3-yla...)
Affinity DataIC50: 9nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332170((S)-2-(4-chlorophenyl)-4-(piperidin-3-ylamino)thia...)
Affinity DataIC50: 9nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332147((S)-2-(2,4-difluorophenyl)-4-(piperidin-3-ylamino)...)
Affinity DataIC50: 9nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332174((S)-2-(4-chlorophenyl)-4-(pyrrolidin-3-ylamino)thi...)
Affinity DataIC50: 14nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332146((S)-2-(1H-indol-6-yl)-4-(piperidin-3-ylamino)thien...)
Affinity DataIC50: 16nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332166((S)-2-(4-(N,N-dimethylsulfamoyl)phenyl)-4-(piperid...)
Affinity DataIC50: 16nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332139((S)-2-(2-methoxyphenyl)-4-(piperidin-3-ylamino)thi...)
Affinity DataIC50: 19nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332165((S)-2-(3-(N,N-dimethylsulfamoyl)phenyl)-4-(piperid...)
Affinity DataIC50: 20nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332137((S)-2-(2-chlorophenyl)-4-(piperidin-3-ylamino)thie...)
Affinity DataIC50: 21nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332128((S)-2-(5-fluoro-2-methoxyphenyl)-4-(piperidin-3-yl...)
Affinity DataIC50: 24nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332158((S)-4-(piperidin-3-ylamino)-2-(quinolin-3-yl)thien...)
Affinity DataIC50: 34nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332167((S)-2-bromo-4-(piperidin-3-ylamino)thieno[3,2-c]py...)
Affinity DataIC50: 56nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332154((S)-4-(piperidin-3-ylamino)-2-(pyrimidin-2-yl)thie...)
Affinity DataIC50: 60nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332145((S)-2-(1H-indol-5-yl)-4-(piperidin-3-ylamino)thien...)
Affinity DataIC50: 60nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332157((S)-4-(piperidin-3-ylamino)-2-(pyridin-3-ylethynyl...)
Affinity DataIC50: 67nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332125((R)-4-(3-aminopiperidin-1-yl)-2-(4-chlorophenyl)th...)
Affinity DataIC50: 148nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332123((S)-2-(4-chlorophenyl)-4-(pyrrolidin-2-ylmethylami...)
Affinity DataIC50: 197nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332126((R)-2-(4-chlorophenyl)-4-(piperidin-3-ylamino)thie...)
Affinity DataIC50: 211nMAssay Description:Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
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