Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50032776
TargetSodium-dependent dopamine transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334460(RTI-229 | CHEMBL1643896 | ((1R,2S,3S,5S)-3-(4-iodo...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50323775(N-((E)-4-Fluorobut-2-en-1-yl)-2beta-carbomethoxy-3...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334460(RTI-229 | CHEMBL1643896 | ((1R,2S,3S,5S)-3-(4-iodo...)
Affinity DataIC50: 991nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50323775(N-((E)-4-Fluorobut-2-en-1-yl)-2beta-carbomethoxy-3...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50323775(N-((E)-4-Fluorobut-2-en-1-yl)-2beta-carbomethoxy-3...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334460(RTI-229 | CHEMBL1643896 | ((1R,2S,3S,5S)-3-(4-iodo...)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334458(N-(3-Fluorobenzyl)-N-methyl-8-aminopentacyclo[5.4....)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in HEK cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50026948((trans) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct...)
Affinity DataKi:  7.20nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50175145(8-(2-aminoethyl)-N-(bis(4-fluorophenyl)methyl)-8-a...)
Affinity DataKi:  12.5nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334461(2-butyl-3-(4-chlorophenyl)-1-azabicyclo[2.2.2]oct-...)
Affinity DataKi:  14nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334459((1S,2S,3S,5R)-methyl 8-(3-iodoallyl)-3-p-tolyl-8-a...)
Affinity DataKi:  17nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  19nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat PC12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50026948((trans) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct...)
Affinity DataKi:  44nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50026948((trans) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct...)
Affinity DataKi:  57nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334456(N-(2-(3'-Fluorophenyl)ethyl)-N-methyl-8-aminopenta...)
Affinity DataKi:  101nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in HEK cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334457(N-(3-Fluorobenzyl)-8-aminopentacyclo[5.4.0.02,6.03...)
Affinity DataKi:  198nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat PC12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334459((1S,2S,3S,5R)-methyl 8-(3-iodoallyl)-3-p-tolyl-8-a...)
Affinity DataKi:  500nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  705nMAssay Description:Inhibition of muscarinic M4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334459((1S,2S,3S,5R)-methyl 8-(3-iodoallyl)-3-p-tolyl-8-a...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334456(N-(2-(3'-Fluorophenyl)ethyl)-N-methyl-8-aminopenta...)
Affinity DataKi:  1.16E+3nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat PC12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of muscarinic M3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334458(N-(3-Fluorobenzyl)-N-methyl-8-aminopentacyclo[5.4....)
Affinity DataKi:  1.57E+3nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat PC12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  1.68E+3nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in HEK cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  1.83E+3nMAssay Description:Inhibition of muscarinic M5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334456(N-(2-(3'-Fluorophenyl)ethyl)-N-methyl-8-aminopenta...)
Affinity DataKi:  2.07E+3nMAssay Description:Inhibition of Alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50175145(8-(2-aminoethyl)-N-(bis(4-fluorophenyl)methyl)-8-a...)
Affinity DataKi:  2.11E+3nMAssay Description:Inhibition of muscarinic M1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334457(N-(3-Fluorobenzyl)-8-aminopentacyclo[5.4.0.02,6.03...)
Affinity DataKi:  2.15E+3nMAssay Description:Inhibition of H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  2.29E+3nMAssay Description:Inhibition of muscarinic M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  2.38E+3nMAssay Description:Inhibition of H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334457(N-(3-Fluorobenzyl)-8-aminopentacyclo[5.4.0.02,6.03...)
Affinity DataKi:  3.44E+3nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in HEK cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  3.62E+3nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  4.42E+3nMAssay Description:Inhibition of H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334456(N-(2-(3'-Fluorophenyl)ethyl)-N-methyl-8-aminopenta...)
Affinity DataKi:  4.45E+3nMAssay Description:Inhibition of H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  5.22E+3nMAssay Description:Inhibition of dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334457(N-(3-Fluorobenzyl)-8-aminopentacyclo[5.4.0.02,6.03...)
Affinity DataKi:  5.88E+3nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  6.02E+3nMAssay Description:Inhibition of 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334456(N-(2-(3'-Fluorophenyl)ethyl)-N-methyl-8-aminopenta...)
Affinity DataKi:  6.09E+3nMAssay Description:Inhibition of 5HT2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  6.98E+3nMAssay Description:Inhibition of 5HT2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334457(N-(3-Fluorobenzyl)-8-aminopentacyclo[5.4.0.02,6.03...)
Affinity DataKi:  7.16E+3nMAssay Description:Inhibition of dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  7.61E+3nMAssay Description:Inhibition of alpha2A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334456(N-(2-(3'-Fluorophenyl)ethyl)-N-methyl-8-aminopenta...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334456(N-(2-(3'-Fluorophenyl)ethyl)-N-methyl-8-aminopenta...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334458(N-(3-Fluorobenzyl)-N-methyl-8-aminopentacyclo[5.4....)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of dopamine D5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334457(N-(3-Fluorobenzyl)-8-aminopentacyclo[5.4.0.02,6.03...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed