Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50033313
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65920(2-[[1-[(5-bromo-2-fluorophenyl)methyl]-3-indolyl]s...)
Affinity DataEC50:  1.38E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65918(VU0405645-1 | cid_44475948 | 2-[4,6-difluoro-1-[[3...)
Affinity DataEC50:  1.85E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65909(cid_44216758 | N-(5-methyl-3-isoxazolyl)-2-[[1-[[3...)
Affinity DataEC50:  2.19E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343186(2-(1-(2-fluoro-5-(1H-pyrazol-4-yl)benzyl)-1H-indol...)
Affinity DataEC50:  3.07E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343174(2-(1-(3-(1-methyl-1H-pyrazol-4-yl)benzyl)-1H-indol...)
Affinity DataEC50:  3.21E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65914(2-[[1-[(3-bromophenyl)methyl]-3-indolyl]sulfonyl]-...)
Affinity DataEC50:  3.79E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343185(2-(1-(2-fluoro-3-(1H-pyrazol-4-yl)benzyl)-1H-indol...)
Affinity DataEC50:  4.40E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65911(cid_44241485 | 2-[1-[(3-chloro-2-fluorophenyl)meth...)
Affinity DataEC50:  5.10E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65916(2-[[1-[(3-fluorophenyl)methyl]-3-indolyl]sulfonyl]...)
Affinity DataEC50:  5.22E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65917(2-[1-[(3-bromophenyl)methyl]-4,6-bis(fluoranyl)ind...)
Affinity DataEC50:  5.37E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65907(VU0366968-1 | 2-[1-[(3-chlorophenyl)methyl]indol-3...)
Affinity DataEC50:  5.82E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65908(VU0366971-1 | cid_44129593 | 2-[[1-[(3-methoxyphen...)
Affinity DataEC50:  6.54E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65913(2-[1-[(2-chlorophenyl)methyl]indol-3-yl]sulfonyl-N...)
Affinity DataEC50:  9.71E+3nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343171(2-(1-(2-fluorobenzyl)-1H-indol-3-ylsulfonyl)-N-(5-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343172(2-(1-(2,4-difluorobenzyl)-1H-indol-3-ylsulfonyl)-N...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343173(2-(1-(2-bromo-4-fluorobenzyl)-1H-indol-3-ylsulfony...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343167(2-(1-(3,5-dibromobenzyl)-1H-indol-3-ylsulfonyl)-N-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343168(2-(1-(3,4-dichlorobenzyl)-1H-indol-3-ylsulfonyl)-N...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343169(N-(5-methylisoxazol-3-yl)-2-(1-(4-(trifluoromethyl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343170(N-(5-methylisoxazol-3-yl)-2-(1-(4-(trifluoromethox...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343178(N-(5-methylisoxazol-3-yl)-2-(1-(3-(6-morpholinopyr...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343179(N-(5-methylisoxazol-3-yl)-2-(1-(3-(6-(piperazin-1-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343180(N-(5-methylisoxazol-3-yl)-2-(1-(3-(6-(pyrrolidin-1...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343181(2-(1-(4-fluoro-3-(1H-pyrazol-4-yl)benzyl)-1H-indol...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343176(2-(1-(3-(1-sec-butyl-1H-pyrazol-4-yl)benzyl)-1H-in...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343177(2-(1-(biphenyl-3-ylmethyl)-1H-indol-3-ylsulfonyl)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65912(cid_44216757 | 2-[1-[[3-(6-chloranylpyridin-3-yl)p...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343184(2-(1-(3-bromo-2-fluorobenzyl)-1H-indol-3-ylsulfony...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343182(2-(1-(3-bromo-4-fluorobenzyl)-1H-indol-3-ylsulfony...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343183(2-(1-(3-chloro-4-fluorobenzyl)-1H-indol-3-ylsulfon...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343165(N-(5-methylisoxazol-3-yl)-2-(1-(3-(trifluoromethyl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343166(2-(1-(3-cyanobenzyl)-1H-indol-3-ylsulfonyl)-N-(5-m...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343162(2-(1-(4-chlorobenzyl)-1H-indol-3-ylsulfonyl)-N-(5-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343163(2-(1-(2-methoxybenzyl)-1H-indol-3-ylsulfonyl)-N-(5...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM50343164(2-(1-(4-methoxybenzyl)-1H-indol-3-ylsulfonyl)-N-(5...)
Affinity DataEC50: >1.00E+4nMAssay Description:Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65913(2-[1-[(2-chlorophenyl)methyl]indol-3-yl]sulfonyl-N...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at M5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65913(2-[1-[(2-chlorophenyl)methyl]indol-3-yl]sulfonyl-N...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65913(2-[1-[(2-chlorophenyl)methyl]indol-3-yl]sulfonyl-N...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at M3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core

Curated by ChEMBL
LigandPNGBDBM65913(2-[1-[(2-chlorophenyl)methyl]indol-3-yl]sulfonyl-N...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at M4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed