Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with all data for entry = 50039383
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi:  0.0360nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50258612(3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)be...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336827(3-[(2-Aminothiazol)-4-ethynyl]-5-fluorobenzonitril...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336830(3-((2-Chlorothiazol)-4-yl)ethynyl)benzonitrile | C...)
Affinity DataKi:  0.270nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336831(3-((2-Chlorothiazol)-4-yl)ethynyl)-5-fluorobenzoni...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336826(3-[(2-Aminothiazol)-4-ethynyl]benzonitrile | CHEMB...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336835(3-((2-Bromothiazol)-4-ethynyl)-5-fluorobenzonitril...)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336839(3-((2-Iodothiazol)-4-ethynyl)-5-fluorobenzonitrile...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336842(3-((2-Fluorothiazol-4-yl)ethynyl)benzonitrile | CH...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336832(2-(3-((2-Chlorothiazol)-4-yl)ethynyl)-phenyl)aceto...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336836(2-(3-((2-Bromothiazol-4-yl)ethynyl)phenyl)acetonit...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336834(3-((2-bromothiazol-4-yl)ethynyl)benzonitrile | CHE...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336844(2-(3-((2-Fluorothiazol-4-yl)ethynyl)phenyl)acetoni...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336838(3-[(2-Iodothiazol)-4-ethynyl]-benzonitrile | CHEMB...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336828(2-(3-((2-Aminothiazol-4-yl)ethynyl)acetonitrile | ...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336833(2-Chloro-4-((3-methoxyphenyl)ethynyl)thiazole | CH...)
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336829(4-(3-Methoxyphenyl)ethynyl(thiazol)-2-amine | CHEM...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336837(2-Bromo-4-((3-methoxyphenyl)ethynyl)thiazole | CHE...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336840(2-(3-((2-Iodothiazol-4-yl)ethynyl)phenyl)acetonitr...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336845(2-Fluoro-4-((3-methoxyphenyl)ethynyl)thiazole | CH...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336846(2-fluoro-4-(phenylethynyl)thiazole | CHEMBL1672290)
Affinity DataKi:  122nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336841(2-Iodo-4-((3-methoxyphenyl)ethynyl)thiazole | CHEM...)
Affinity DataKi:  133nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to SERT receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to sigma 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT5A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT1B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT1E receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to dopamine D4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to dopamine D5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to KORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic Alpha-1B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic Alpha-1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic Alpha-2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic beta1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to adrenergic beta2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
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