Compile Data Set for Download or QSAR
Report error Found 91 Enz. Inhib. hit(s) with all data for entry = 50033276
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342639(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-methyltetra...)
Affinity DataIC50: 0.210nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342634(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-methoxyprop...)
Affinity DataIC50: 0.240nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342638(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(3-methoxypent...)
Affinity DataIC50: 0.25nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342625(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-methoxyprop...)
Affinity DataIC50: 0.310nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342636(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-ethoxypropa...)
Affinity DataIC50: 0.320nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342612(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2,2,2-trifluo...)
Affinity DataIC50: 0.370nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342630(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2,2,2-trifluo...)
Affinity DataIC50: 0.410nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342638(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(3-methoxypent...)
Affinity DataIC50: 0.420nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342625(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-methoxyprop...)
Affinity DataIC50: 0.610nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342633(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(methoxymethyl...)
Affinity DataIC50: 0.610nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342623(N-((6S,9R)-6-(2,3-difluorophenyl)-3-isopropyl-6,7,...)
Affinity DataIC50: 0.620nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342634(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-methoxyprop...)
Affinity DataIC50: 0.630nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342624(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(methoxymethyl...)
Affinity DataIC50: 0.630nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342637(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-(2,2,2-trif...)
Affinity DataIC50: 0.650nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342639(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-methyltetra...)
Affinity DataIC50: 0.760nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342629(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-methoxyprop...)
Affinity DataIC50: 0.820nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342632(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2,2,2-trifluo...)
Affinity DataIC50: 0.830nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342635(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-hydroxyprop...)
Affinity DataIC50: 0.860nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342626(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2,2,2-trifluo...)
Affinity DataIC50: 0.940nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342632(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2,2,2-trifluo...)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342629(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-methoxyprop...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342627(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(1-(trifluorom...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342635(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-hydroxyprop...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342611(N-((6S,9R)-3-cyclopropyl-6-(2,3-difluorophenyl)-6,...)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342628(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(methoxymethyl...)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342633(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(methoxymethyl...)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342624(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(methoxymethyl...)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224431(N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-t...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342630(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2,2,2-trifluo...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342631(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2,2,2-trifluo...)
Affinity DataIC50: 2.30nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342611(N-((6S,9R)-3-cyclopropyl-6-(2,3-difluorophenyl)-6,...)
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342612(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2,2,2-trifluo...)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342621(N-((6S,9R)-6-(2,3-difluorophenyl)-3-phenyl-6,7,8,9...)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342631(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2,2,2-trifluo...)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342636(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2-ethoxypropa...)
Affinity DataIC50: 2.90nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342623(N-((6S,9R)-6-(2,3-difluorophenyl)-3-isopropyl-6,7,...)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342622(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(thiazol-2-yl)...)
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342626(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(2,2,2-trifluo...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342617(N-((6S,9R)-6-(2,3-difluorophenyl)-3-methyl-6,7,8,9...)
Affinity DataIC50: 4.10nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342620((6S,9R)-6-(2,3-difluorophenyl)-N,N-dimethyl-9-(4-(...)
Affinity DataIC50: 4.10nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342628(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(methoxymethyl...)
Affinity DataIC50: 4.30nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342613(N-((6S,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahyd...)
Affinity DataIC50: 6.70nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342614(N-((6S,9R)-6-(2,3-difluorophenyl)-2-(2,2,2-trifluo...)
Affinity DataIC50: 7.20nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342620((6S,9R)-6-(2,3-difluorophenyl)-N,N-dimethyl-9-(4-(...)
Affinity DataIC50: 7.40nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342618(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(hydroxymethyl...)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342627(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(1-(trifluorom...)
Affinity DataIC50: 8.60nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342616(N-((6S,9R)-6-(2,3-difluorophenyl)-2-methyl-6,7,8,9...)
Affinity DataIC50: 8.70nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224431(N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-t...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342618(N-((6S,9R)-6-(2,3-difluorophenyl)-3-(hydroxymethyl...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342617(N-((6S,9R)-6-(2,3-difluorophenyl)-3-methyl-6,7,8,9...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
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