Compile Data Set for Download or QSAR
Report error Found 100 Enz. Inhib. hit(s) with all data for entry = 50033278
LigandPNGBDBM50342677(tert-butyl 1'-(pyrazin-2-yl)-4,4'-bipiperidine-1-c...)
Affinity DataEC50:  142nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342687(1-(5-fluoropyridin-2-yl)-1'-(4-(methylsulfonyl)phe...)
Affinity DataEC50:  206nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342686(1-(5-chloropyridin-2-yl)-1'-(4-(methylsulfonyl)phe...)
Affinity DataEC50:  131nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342685(1-(5-methylpyrimidin-2-yl)-1'-(4-(methylsulfonyl)p...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342684(1-(4-(methylsulfonyl)phenyl)-1'-(pyrimidin-2-yl)-4...)
Affinity DataEC50:  887nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342683(1-(4-(methylsulfonyl)phenyl)-1'-(pyrazin-2-yl)-4,4...)
Affinity DataEC50:  239nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342682(1-(4-(methylsulfonyl)phenyl)-1'-(pyridin-2-yl)-4,4...)
Affinity DataEC50:  682nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342681(tert-butyl 1'-(6-cyano-2-methylpyrimidin-4-yl)-4,4...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342680(tert-butyl 1'-(2-cyano-6-methylpyrimidin-4-yl)-4,4...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342679(tert-butyl 1'-(6-cyanopyrimidin-4-yl)-4,4'-bipiper...)
Affinity DataEC50:  31nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342678(tert-butyl 1'-(2-cyanopyrimidin-4-yl)-4,4'-bipiper...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342688(1-(5-methylpyridin-2-yl)-1'-(4-(methylsulfonyl)phe...)
Affinity DataEC50:  73nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342676(tert-butyl 1'-(pyrimidin-2-yl)-4,4'-bipiperidine-1...)
Affinity DataEC50:  523nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342675(tert-butyl 1'-(pyrimidin-4-yl)-4,4'-bipiperidine-1...)
Affinity DataEC50:  379nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342674(tert-butyl 1'-(pyridin-2-yl)-4,4'-bipiperidine-1-c...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342673(tert-butyl 1'-(4-carbamoylphenyl)-4,4'-bipiperidin...)
Affinity DataEC50:  165nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342672(tert-butyl 1'-(4-(methylthio)phenyl)-4,4'-bipiperi...)
Affinity DataEC50:  513nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342671(tert-butyl 1'-(4-acetylphenyl)-4,4'-bipiperidine-1...)
Affinity DataEC50:  341nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342670(tert-butyl 1'-(4-(methylsulfinyl)phenyl)-4,4'-bipi...)
Affinity DataEC50:  132nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342668(tert-butyl 1'-(4-(methylsulfonyl)phenyl)-4,4'-bipi...)
Affinity DataEC50:  36nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342667(tert-butyl 1'-p-tolyl-4,4'-bipiperidine-1-carboxyl...)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342696((rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperid...)
Affinity DataEC50:  9nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342702(6-methyl-2-(2-((1S,2R)-2-(1-(5-methylpyrimidin-2-y...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342701(2-(4-((1R,2S)-2-(2-(5-(1H-1,2,3-triazol-1-yl)pyrid...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342700(2-(4-((1R,2S)-2-(2-(4-(1H-1,2,3-triazol-1-yl)pheno...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342699(5-chloro-2-(4-((1R,2S)-2-(2-(5-(methylsulfonyl)pyr...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342698((rac)-cis-4-((2-((1-(5-chloropyrimidin-2-yl)piperi...)
Affinity DataEC50:  36nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342698((rac)-cis-4-((2-((1-(5-chloropyrimidin-2-yl)piperi...)
Affinity DataEC50:  36nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342697((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342697((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342697((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342696((rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperid...)
Affinity DataEC50:  9nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342665(tert-butyl 1'-phenyl-4,4'-bipiperidine-1-carboxyla...)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342703(rac-4-(3-(2-(3-(1-(5-chloropyrimidin-2-yl)piperidi...)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342703(rac-4-(3-(2-(3-(1-(5-chloropyrimidin-2-yl)piperidi...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342695(4-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiper...)
Affinity DataEC50:  64nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342694(2-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiper...)
Affinity DataEC50:  82nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342693(2-methyl-6-(1'-(5-methylpyrimidin-2-yl)-4,4'-bipip...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342692(4-(1'-(5-chloropyrimidin-2-yl)-4,4'-bipiperidin-1-...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342691(1-(5-chloropyrimidin-2-yl)-1'-(4-(methylsulfonyl)p...)
Affinity DataEC50:  8nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342690(1-(4-(methylsulfonyl)phenyl)-1'-(5-(trifluoromethy...)
Affinity DataEC50:  8nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342689(6-(1'-(4-(methylsulfonyl)phenyl)-4,4'-bipiperidin-...)
Affinity DataEC50:  41nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342674(tert-butyl 1'-(pyridin-2-yl)-4,4'-bipiperidine-1-c...)
Affinity DataEC50:  831nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342684(1-(4-(methylsulfonyl)phenyl)-1'-(pyrimidin-2-yl)-4...)
Affinity DataEC50:  98nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342683(1-(4-(methylsulfonyl)phenyl)-1'-(pyrazin-2-yl)-4,4...)
Affinity DataEC50:  201nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342682(1-(4-(methylsulfonyl)phenyl)-1'-(pyridin-2-yl)-4,4...)
Affinity DataEC50:  39nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342681(tert-butyl 1'-(6-cyano-2-methylpyrimidin-4-yl)-4,4...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342680(tert-butyl 1'-(2-cyano-6-methylpyrimidin-4-yl)-4,4...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342679(tert-butyl 1'-(6-cyanopyrimidin-4-yl)-4,4'-bipiper...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342678(tert-butyl 1'-(2-cyanopyrimidin-4-yl)-4,4'-bipiper...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
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