Compile Data Set for Download or QSAR
Report error Found 157 Enz. Inhib. hit(s) with all data for entry = 50033317
LigandPNGBDBM50343205(N-(6-(6-Chloro-5-(2-(trifluoromethyl)phenylsulfona...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343207(N-(6-(6-Chloro-5-(4-(trifluoromethyl)phenylsulfona...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343204(N-(6-(6-Chloro-5-(phenylsulfonamido)pyridin-3-yl)b...)
Affinity DataIC50: 1nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343206(N-(6-(6-Chloro-5-(3-(trifluoromethyl)phenylsulfona...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343212(N-(6-(6-Chloro-5-(4-tert-butylphenylsulfonamido)py...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343213(N-(6-(6-Chloro-5-(2-fluorophenylsulfonamido)pyridi...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343208(N-(6-(6-Chloro-5-(2-chlorophenylsulfonamido)pyridi...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343209(N-(6-(6-Chloro-5-(3-chlorophenylsulfonamido)pyridi...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343211(N-(6-(5-(3-tert-Butylphenylsulfonamido)-6-chloropy...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343209(N-(6-(6-Chloro-5-(3-chlorophenylsulfonamido)pyridi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343203(N-(6-(6-Chloro-5-(4-methoxyphenylsulfonamido)pyrid...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343210(N-(6-(6-Chloro-5-(4-chlorophenylsulfonamido)pyridi...)
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343208(N-(6-(6-Chloro-5-(2-chlorophenylsulfonamido)pyridi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343210(N-(6-(6-Chloro-5-(4-chlorophenylsulfonamido)pyridi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343206(N-(6-(6-Chloro-5-(3-(trifluoromethyl)phenylsulfona...)
Affinity DataIC50: 1nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343205(N-(6-(6-Chloro-5-(2-(trifluoromethyl)phenylsulfona...)
Affinity DataIC50: 1nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343213(N-(6-(6-Chloro-5-(2-fluorophenylsulfonamido)pyridi...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343214(N-(6-(6-Chloro-5-(3-fluorophenylsulfonamido)pyridi...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343200(N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridi...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human PI3Kdelta expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343202(N-(6-(5-(4-Methoxyphenylsulfonamido)-6-methylpyrid...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343200(N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridi...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343201(N-(6-(6-Cyano-5-(4-methoxyphenylsulfonamido)pyridi...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343204(N-(6-(6-Chloro-5-(phenylsulfonamido)pyridin-3-yl)b...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343201(N-(6-(6-Cyano-5-(4-methoxyphenylsulfonamido)pyridi...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343197(N-(6-(5-(4-Methoxyphenylsulfonamido)pyridin-3-yl)b...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343207(N-(6-(6-Chloro-5-(4-(trifluoromethyl)phenylsulfona...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343200(N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridi...)
Affinity DataKi:  2nMAssay Description:Inhibition of human PI3Kbeta expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343200(N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridi...)
Affinity DataIC50: 2nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343212(N-(6-(6-Chloro-5-(4-tert-butylphenylsulfonamido)py...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343203(N-(6-(6-Chloro-5-(4-methoxyphenylsulfonamido)pyrid...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343211(N-(6-(5-(3-tert-Butylphenylsulfonamido)-6-chloropy...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343214(N-(6-(6-Chloro-5-(3-fluorophenylsulfonamido)pyridi...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343200(N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridi...)
Affinity DataIC50: 3nMAssay Description:Inhibition of DNA-PK after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343200(N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridi...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of human PI3Kgamma expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343208(N-(6-(6-Chloro-5-(2-chlorophenylsulfonamido)pyridi...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343204(N-(6-(6-Chloro-5-(phenylsulfonamido)pyridin-3-yl)b...)
Affinity DataIC50: 5nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343203(N-(6-(6-Chloro-5-(4-methoxyphenylsulfonamido)pyrid...)
Affinity DataIC50: 5nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343202(N-(6-(5-(4-Methoxyphenylsulfonamido)-6-methylpyrid...)
Affinity DataIC50: 6nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343200(N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridi...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343212(N-(6-(6-Chloro-5-(4-tert-butylphenylsulfonamido)py...)
Affinity DataIC50: 7nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343205(N-(6-(6-Chloro-5-(2-(trifluoromethyl)phenylsulfona...)
Affinity DataIC50: 8nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343210(N-(6-(6-Chloro-5-(4-chlorophenylsulfonamido)pyridi...)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343198(N-(6-(6-(4-Methoxyphenylsulfonamido)pyrazin-2-yl)b...)
Affinity DataKi:  9nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343213(N-(6-(6-Chloro-5-(2-fluorophenylsulfonamido)pyridi...)
Affinity DataIC50: 9nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343197(N-(6-(5-(4-Methoxyphenylsulfonamido)pyridin-3-yl)b...)
Affinity DataIC50: 11nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343209(N-(6-(6-Chloro-5-(3-chlorophenylsulfonamido)pyridi...)
Affinity DataIC50: 12nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343206(N-(6-(6-Chloro-5-(3-(trifluoromethyl)phenylsulfona...)
Affinity DataIC50: 12nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343214(N-(6-(6-Chloro-5-(3-fluorophenylsulfonamido)pyridi...)
Affinity DataIC50: 13nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343196(N-(6-(2-(4-Methoxyphenylsulfonamido)pyridin-4-yl)b...)
Affinity DataKi:  13nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343211(N-(6-(5-(3-tert-Butylphenylsulfonamido)-6-chloropy...)
Affinity DataIC50: 13nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
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