Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50033166
Target5-hydroxytryptamine receptor 2B(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataIC50: 5.13E+3nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human ERG by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataKi:  0.260nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340726(CHEMBL1668500 | US8552005, 1.1(5) | 5,7-dimethyl-2...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340730(CHEMBL1762568 | US8552005, 1.1(6) | 5,7-Dimethyl-2...)
Affinity DataKi:  1.91nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340726(CHEMBL1668500 | US8552005, 1.1(5) | 5,7-dimethyl-2...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340731(CHEMBL1762569 | US8829009, 1.1(2) | N,N,5,7-Tetram...)
Affinity DataKi:  14.5nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340728(US8552005, 1.1(2) | CHEMBL1762571 | 2-{[5,7-Dimeth...)
Affinity DataKi:  22.2nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340727(US8552005, 1.1(13) | CHEMBL1762570 | 2,5,7-Triimet...)
Affinity DataKi:  68.4nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340727(US8552005, 1.1(13) | CHEMBL1762570 | 2,5,7-Triimet...)
Affinity DataKi:  88.8nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340729(CHEMBL1429795 | US8552005, 1.1(1) | 5,7-Dimethyl-3...)
Affinity DataKi:  237nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340728(US8552005, 1.1(2) | CHEMBL1762571 | 2-{[5,7-Dimeth...)
Affinity DataKi:  283nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340732(N-[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]p...)
Affinity DataKi:  489nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340729(CHEMBL1429795 | US8552005, 1.1(1) | 5,7-Dimethyl-3...)
Affinity DataKi:  561nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340733(N'-[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]...)
Affinity DataKi:  764nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | US8829009, 1.1(1) | N,5,7-trimethy...)
Affinity DataKi:  1.04E+3nMAssay Description:Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340734(5,7-Dimethyl-3-(phenylsulfonyl)-2-piperazin-1-ylpy...)
Affinity DataKi:  1.38E+3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340735((2-{[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a...)
Affinity DataKi:  2.20E+3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340736(N'-[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]...)
Affinity DataKi:  2.60E+3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340737(5,7-Dimethyl-2-(methylsulfinyl)-3-(phenylsulfonyl)...)
Affinity DataKi:  2.96E+3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed