Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 50033104
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Abl1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of DDR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339615((2S)-7-({2-[(Cyclopropylcarbonyl)amino]pyridin-4-y...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339613((2S)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339616(7-({2-[(Cyclopropylcarbonyl)amino]pyridin-4-yl}oxy...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339614((2R)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 6nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339611((2S)-7-{[2-(acetylamino)pyridin-4-yl]oxy}-N-[3-(am...)
Affinity DataIC50: 6nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339612(N-[3-(Aminomethyl)-5-(trifluoromethyl)phenyl]-7-({...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 7nMAssay Description:Inhibition of DDR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339623(4-[3-(3-{[4-Chloro-3-(trifluoromethyl)phenyl]amino...)
Affinity DataIC50: 9nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339622(4-[4-(3-{[4-Chloro-3-(trifluoromethyl)phenyl]amino...)
Affinity DataIC50: 10nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 11nMAssay Description:Inhibition of EPHA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339610(4-{[7-({[3-(Aminomethyl)-5-(trifluoromethyl)phenyl...)
Affinity DataIC50: 11nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339625(4-{[7-({[4-(Aminomethyl)-3-(trifluoromethyl)phenyl...)
Affinity DataIC50: 16nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 18nMAssay Description:Inhibition of EPHA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339624(rac-4-{[7-({[4-Chloro-3-(trifluoromethyl)phenyl]am...)
Affinity DataIC50: 28nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 42nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339621(3-[(methylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,8-...)
Affinity DataIC50: 45nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 50nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 59nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 60nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339619(N-[(2R)-7-({2-[(cyclopropylcarbonyl)amino]pyridin-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339618((2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)...)
Affinity DataIC50: 79nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 91nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339617((2S)-N-[3-[(Isopropylamino)methyl]-5-(trifluoromet...)
Affinity DataIC50: 110nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339615((2S)-7-({2-[(Cyclopropylcarbonyl)amino]pyridin-4-y...)
Affinity DataIC50: 130nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339613((2S)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 130nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339612(N-[3-(Aminomethyl)-5-(trifluoromethyl)phenyl]-7-({...)
Affinity DataIC50: 150nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339611((2S)-7-{[2-(acetylamino)pyridin-4-yl]oxy}-N-[3-(am...)
Affinity DataIC50: 150nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 170nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339616(7-({2-[(Cyclopropylcarbonyl)amino]pyridin-4-yl}oxy...)
Affinity DataIC50: 190nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 190nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 610nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339614((2R)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 780nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339620(N-[(2S)-7-({2-[(Cyclopropylcarbonyl)amino]pyridin-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339610(4-{[7-({[3-(Aminomethyl)-5-(trifluoromethyl)phenyl...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339624(rac-4-{[7-({[4-Chloro-3-(trifluoromethyl)phenyl]am...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339625(4-{[7-({[4-(Aminomethyl)-3-(trifluoromethyl)phenyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339622(4-[4-(3-{[4-Chloro-3-(trifluoromethyl)phenyl]amino...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339623(4-[3-(3-{[4-Chloro-3-(trifluoromethyl)phenyl]amino...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed