Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50033106
TargetCytochrome P450 11B2, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone/11-deoxycorticosteroneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP11B1 expressed in Chinese hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone/11-deoxycorticosteroneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339655(7-(3,4-Difluorophenoxy)-4-(1H-imidazol-1-ylmethyl)...)
Affinity DataIC50: 47nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM9475(4-(1H-Imidazol-1-ylmethyl)-7-phenoxy-2H-chromen-2-...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 52nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339659(rac-4-[1H-Imidazol-1-yl(phenyl)methyl]-7-phenoxy-2...)
Affinity DataIC50: 67nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339654(7-(3,5-Difluorophenoxy)-4-(1H-imidazol-1-ylmethyl)...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339647(7-(3-Chlorophenoxy)-4-(1H-imidazol-1-ylmethyl)-2H-...)
Affinity DataIC50: 72nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM9485(7-(benzyloxy)-4-(1H-imidazol-1-ylmethyl)-2H-chrome...)
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP11B1 expressed in Chinese hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone/11-deoxycorticosteroneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339646(7-(3-Fluorophenoxy)-4-(1H-imidazol-1-ylmethyl)-2H-...)
Affinity DataIC50: 72nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339653(7-[4-(Dimethylamino)phenoxy]-4-(1H-imidazol-1-ylme...)
Affinity DataIC50: 81nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339656(7-Anilino-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-...)
Affinity DataIC50: 105nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339650(7-(4-Chlorophenoxy)-4-(1H-imidazol-1-ylmethyl)-2H-...)
Affinity DataIC50: 112nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339665(7-[(3-Fluorobenzyl)oxy]-4-(1H-imidazol-1-ylmethyl)...)
Affinity DataIC50: 113nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339664(4-(1H-Imidazol-1-ylmethyl)-7-[(3-methylbenzyl)oxy]...)
Affinity DataIC50: 114nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339642(4-(1H-Imidazol-1-ylmethyl)-7-[(4-methoxybenzyl)oxy...)
Affinity DataIC50: 127nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339666(7-[(3-Chlorobenzyl)oxy]-4-(1H-imidazol-1-ylmethyl)...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339669(4-(1H-Imidazol-1-ylmethyl)-7-[(3-nitrobenzyl)oxy]-...)
Affinity DataIC50: 141nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM9485(7-(benzyloxy)-4-(1H-imidazol-1-ylmethyl)-2H-chrome...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339651(4-{[4-(1H-Imidazol-1-ylmethyl)-2-oxo-2H-chromen-7-...)
Affinity DataIC50: 164nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339645(7-[(3,4-Difluorobenzyl)oxy]-4-(1H-imidazol-1-ylmet...)
Affinity DataIC50: 165nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339644(7-[(3,5-Difluorobenzyl)oxy]-4-(1H-imidazol-1-ylmet...)
Affinity DataIC50: 169nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339641(7-[(4-Chlorobenzyl)oxy]-4-(1H-imidazol-1-ylmethyl)...)
Affinity DataIC50: 178nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339668(4-(1H-Imidazol-1-ylmethyl)-7-{[3-(trifluoromethoxy...)
Affinity DataIC50: 207nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339667(4-(1H-Imidazol-1-ylmethyl)-7-{[3-(trifluoromethyl)...)
Affinity DataIC50: 235nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339640(7-[(4-Fluorobenzyl)oxy]-4-(1H-imidazol-1-ylmethyl)...)
Affinity DataIC50: 267nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM9471(4-(1H-Imidazol-1-ylmethyl)-7-methoxy-2H-chromen-2-...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM9485(7-(benzyloxy)-4-(1H-imidazol-1-ylmethyl)-2H-chrome...)
Affinity DataIC50: 289nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone/11-deoxycorticosteroneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339648(4-(1H-Imidazol-1-ylmethyl)-7-(3-methoxyphenoxy)-2H...)
Affinity DataIC50: 292nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339652(7-(4-Acetylphenoxy)-4-(1H-imidazol-1-ylmethyl)-2H-...)
Affinity DataIC50: 296nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339663(rac-3-[1H-Imidazol-1-yl(phenyl)methyl]-7-phenoxy-2...)
Affinity DataIC50: 313nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339660(rac-7-(3,4-Difluorophenoxy)-4-[1H-imidazol-1-yl(ph...)
Affinity DataIC50: 317nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339658(rac-4-[1H-Imidazol-1-yl(phenyl)methyl]-7-methoxy-2...)
Affinity DataIC50: 455nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339643(4-(1H-Imidazol-1-ylmethyl)-7-[(4-trifluoromethoxyb...)
Affinity DataIC50: 481nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339661(rac-4-[(4-Chlorophenyl)(1H-imidazol-1-yl)methyl]-7...)
Affinity DataIC50: 532nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339649(4-(1H-Imidazol-1-ylmethyl)-7-(4-methylphenoxy)-2H-...)
Affinity DataIC50: 690nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339655(7-(3,4-Difluorophenoxy)-4-(1H-imidazol-1-ylmethyl)...)
Affinity DataIC50: 933nMAssay Description:Inhibition of human CYP11B1 expressed in Chinese hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone/11-deoxycorticosteroneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339655(7-(3,4-Difluorophenoxy)-4-(1H-imidazol-1-ylmethyl)...)
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone/11-deoxycorticosteroneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM9469(CHEMBL387892 | 3-(1H-Imidazol-1-ylmethyl)-7-methox...)
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339657(7-Hydroxy-4-(1H-Imidazol-1-ylmethyl)-2H-chromen-2-...)
Affinity DataIC50: 3.75E+3nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50339662(rac-4-[1H-Imidazol-1-yl(2-oxo-7-phenoxy-2H-chromen...)
Affinity DataIC50: 4.01E+3nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli using progesterone as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed