Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50022511
TargetSerine/threonine-protein kinase mTOR(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 4nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 7nMAssay Description:Competitive inhibition of mTORC2 immunoprecipitated from human HeLa cells using His-tagged 4E-BP1 as substrate incubated for 30 mins in presence of A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50356877(CHEMBL1614710)
Affinity DataIC50: 9nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 9nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 11nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 22nMAssay Description:Competitive inhibition of mTORC1 immunoprecipitated from human HeLa cells using His-tagged 4E-BP1 as substrate incubated for 30 mins in presence of A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 29nMAssay Description:Competitive inhibition of mTORC1 immunoprecipitated from human HeLa cells using His-tagged 4E-BP1 as substrate incubated for 30 mins in presence of A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 65nMAssay Description:Competitive inhibition of mTORC2 immunoprecipitated from human HeLa cells using His-tagged 4E-BP1 as substrate incubated for 30 mins in presence of A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 190nMAssay Description:Inhibition of PI3Kalpha (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 420nMAssay Description:Inhibition of PI3Kgamma (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 460nMAssay Description:Inhibition of PI3Kgamma (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DNA-PK activity (unknown origin) presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mTOR (unknown origin) assessed as reduction in 4E-BP1 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of mTOR (unknown origin) assessed as reduction in 4E-BP1 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of DNA-PK activity (unknown origin) presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of DNA-PK (unknown origin) assessed as reduction in phosphorylated RPA32 level by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PI3Kbeta (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of SRC (unknown origin) assessed as reduction in phosphorylated FAK level by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of SRC (unknown origin) assessed as reduction in phosphorylated FAK level by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of EphA2 phosphorylation (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of DNA-PK (unknown origin) assessed as reduction in phosphorylated RPA32 level by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of VEGFR2 phosphorylation (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of EphA2 phosphorylation (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of EGFR phosphorylation (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of EGFR phosphorylation (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50652797(CHEMBL5661831)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of VEGFR2 phosphorylation (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed