Compile Data Set for Download or QSAR
Report error Found 177 Enz. Inhib. hit(s) with all data for entry = 50040835
Target5-hydroxytryptamine receptor 1A(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataEC50:  2.10E+3nMAssay Description:Agonist activity at human 5HT3A receptor expressed in xenopus oocytes by electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1B(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataEC50:  120nMAssay Description:Partial agonist activity at human 5HT1B receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM85330(NSC_68647 | CAS_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataIC50: 0.0900nMAssay Description:Antagonist activity at human 5HT3A receptor expressed in xenopus oocytes assessed as inhibition of 5HT-induced effect by electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM85330(NSC_68647 | CAS_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataIC50: 0.160nMAssay Description:Binding affinity to rat 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataIC50: 0.180nMAssay Description:Binding affinity to rat 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM25870(CITALOPRAM HYDROBROMIDE | [3H]Escitalopram | Escit...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400901(CHEMBL2204361)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400889(CHEMBL2204357)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400893(CHEMBL2205053)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400903(CHEMBL2204359)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataIC50: 5.40nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400892(CHEMBL2205054)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400879(CHEMBL2205046)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400904(CHEMBL2204358)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400888(CHEMBL2205037)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400883(CHEMBL2205042)
Affinity DataIC50: 8nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400887(CHEMBL2205038)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400899(CHEMBL2204363)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400900(CHEMBL2204362)
Affinity DataIC50: 11nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human 5HT3A receptor expressed in xenopus oocytes assessed as inhibition of 5HT-induced effect by electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400882(CHEMBL2205043)
Affinity DataIC50: 13nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400894(CHEMBL2205052)
Affinity DataIC50: 15nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400890(CHEMBL2204356)
Affinity DataIC50: 17nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400880(CHEMBL2205045)
Affinity DataIC50: 18nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400885(CHEMBL2205040)
Affinity DataIC50: 20nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400890(CHEMBL2204356)
Affinity DataIC50: 21nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400910(CHEMBL2204365)
Affinity DataIC50: 25nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400882(CHEMBL2205043)
Affinity DataIC50: 37nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400891(CHEMBL2204355)
Affinity DataIC50: 37nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400911(CHEMBL2204364)
Affinity DataIC50: 44nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400882(CHEMBL2205043)
Affinity DataIC50: 45nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400895(CHEMBL2205051)
Affinity DataIC50: 51nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400898(CHEMBL2205048)
Affinity DataIC50: 53nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400897(CHEMBL2205049)
Affinity DataIC50: 54nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400881(CHEMBL2205044)
Affinity DataIC50: 67nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400886(CHEMBL2205039)
Affinity DataIC50: 68nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400880(CHEMBL2205045)
Affinity DataIC50: 110nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400892(CHEMBL2205054)
Affinity DataIC50: 120nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400906(CHEMBL2205034)
Affinity DataIC50: 130nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400877(CHEMBL2205036)
Affinity DataIC50: 150nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400889(CHEMBL2204357)
Affinity DataIC50: 170nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400909(CHEMBL2205031)
Affinity DataIC50: 200nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400905(CHEMBL2205035)
Affinity DataIC50: 250nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400903(CHEMBL2204359)
Affinity DataIC50: 250nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400899(CHEMBL2204363)
Affinity DataIC50: 320nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400896(CHEMBL2205050)
Affinity DataIC50: 330nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400884(CHEMBL2205041)
Affinity DataIC50: 390nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400882(CHEMBL2205043)
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant CYP2D6 using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy- 4-methylcoumarin after 45 mins by fluorescence spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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