Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50033771
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 0.810nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351015(CHEMBL1819176)
Affinity DataIC50: 1.10nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351016(CHEMBL1819177)
Affinity DataIC50: 12nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351020(CHEMBL1819175)
Affinity DataIC50: 14nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351013(CHEMBL1819173)
Affinity DataIC50: 15nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351011(CHEMBL1819171)
Affinity DataIC50: 17nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351020(CHEMBL1819175)
Affinity DataIC50: 25nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351013(CHEMBL1819173)
Affinity DataIC50: 28nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351019(CHEMBL1819180)
Affinity DataIC50: 29nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351012(CHEMBL1819172)
Affinity DataIC50: 34nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351012(CHEMBL1819172)
Affinity DataIC50: 38nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351018(CHEMBL1819179)
Affinity DataIC50: 41nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351011(CHEMBL1819171)
Affinity DataIC50: 43nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351010(CHEMBL1819170)
Affinity DataIC50: 45nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351015(CHEMBL1819176)
Affinity DataIC50: 64nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351009(CHEMBL1819169)
Affinity DataIC50: 69nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351010(CHEMBL1819170)
Affinity DataIC50: 91nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351009(CHEMBL1819169)
Affinity DataIC50: 101nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351014(CHEMBL1819174)
Affinity DataIC50: 101nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 250nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351018(CHEMBL1819179)
Affinity DataIC50: 258nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351014(CHEMBL1819174)
Affinity DataIC50: 283nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351017(CHEMBL1819178)
Affinity DataIC50: 310nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351019(CHEMBL1819180)
Affinity DataIC50: 400nMAssay Description:Inhibition of BACE1 expressed in baculovirus assessed as inhibition of amyloid beta-42 production after 60 mins by spectrofluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351019(CHEMBL1819180)
Affinity DataIC50: 455nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351015(CHEMBL1819176)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 expressed in baculovirus assessed as inhibition of amyloid beta-42 production after 60 mins by spectrofluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351016(CHEMBL1819177)
Affinity DataIC50: 1.66E+3nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351017(CHEMBL1819178)
Affinity DataIC50: 7.28E+3nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of BACE1 expressed in baculovirus assessed as inhibition of amyloid beta-42 production after 60 mins by spectrofluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351015(CHEMBL1819176)
Affinity DataKi:  1nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed