Compile Data Set for Download or QSAR
Report error Found 67 Enz. Inhib. hit(s) with all data for entry = 50033863
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352815(CHEMBL1823655)
Affinity DataIC50: 7nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352823(CHEMBL1823663)
Affinity DataIC50: 7nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352839(CHEMBL1823651)
Affinity DataIC50: 20nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352813(CHEMBL1823653)
Affinity DataIC50: 20nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352824(CHEMBL1823630)
Affinity DataIC50: 20nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352814(CHEMBL1823654)
Affinity DataIC50: 30nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352844(CHEMBL1823649)
Affinity DataIC50: 39nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352835(CHEMBL1823641)
Affinity DataIC50: 40nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352837(CHEMBL1823643)
Affinity DataIC50: 40nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50: 50nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352833(CHEMBL1823639)
Affinity DataIC50: 70nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352832(CHEMBL1823638)
Affinity DataIC50: 80nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352816(CHEMBL1823656)
Affinity DataIC50: 110nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352836(CHEMBL1823642)
Affinity DataIC50: 120nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352846(CHEMBL1823652)
Affinity DataIC50: 140nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352838(CHEMBL1823644)
Affinity DataIC50: 140nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352834(CHEMBL1823640)
Affinity DataIC50: 190nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352824(CHEMBL1823630)
Affinity DataIC50: 190nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352831(CHEMBL1823637)
Affinity DataIC50: 200nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352821(CHEMBL1823661)
Affinity DataIC50: 240nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352815(CHEMBL1823655)
Affinity DataIC50: 240nMAssay Description:Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50: 250nMAssay Description:Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352842(CHEMBL1823647)
Affinity DataIC50: 250nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352824(CHEMBL1823630)
Affinity DataIC50: 300nMAssay Description:Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352843(CHEMBL1823648)
Affinity DataIC50: 330nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352840(CHEMBL1823645)
Affinity DataIC50: 350nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352823(CHEMBL1823663)
Affinity DataIC50: 360nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352839(CHEMBL1823651)
Affinity DataIC50: 390nMAssay Description:Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352827(CHEMBL1823633)
Affinity DataIC50: 400nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352841(CHEMBL1823646)
Affinity DataIC50: 460nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352815(CHEMBL1823655)
Affinity DataIC50: 680nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352826(CHEMBL1823632)
Affinity DataIC50: 850nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352829(CHEMBL1823635)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352828(CHEMBL1823634)
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352820(CHEMBL1823660)
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352822(CHEMBL1823662)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352830(CHEMBL1823636)
Affinity DataIC50: 2.68E+3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352825(CHEMBL1823631)
Affinity DataIC50: 3.38E+3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352817(CHEMBL1823657)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352845(CHEMBL1823650)
Affinity DataIC50: 6.85E+3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352816(CHEMBL1823656)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352818(CHEMBL1823658)
Affinity DataIC50: 1.27E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352826(CHEMBL1823632)
Affinity DataIC50: 1.97E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50352819(CHEMBL1823659)
Affinity DataIC50: 2.04E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352813(CHEMBL1823653)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352822(CHEMBL1823662)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352819(CHEMBL1823659)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352818(CHEMBL1823658)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352821(CHEMBL1823661)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
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