Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50033866
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352936(CHEMBL1824915)
Affinity DataIC50: 6.40nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352935(CHEMBL1824916)
Affinity DataIC50: 7.20nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352948(CHEMBL1824904)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352947(CHEMBL1824905)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352943(CHEMBL1824909)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at mouse SMO expressed in NIH/3T3 cells transfected with Gli-dependent luciferase-reporter after 15 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352935(CHEMBL1824916)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at mouse SMO expressed in NIH/3T3 cells transfected with Gli-dependent luciferase-reporter after 15 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352949(CHEMBL1824917)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352944(CHEMBL1824908)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352934(CHEMBL1824918)
Affinity DataIC50: 28nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352943(CHEMBL1824909)
Affinity DataIC50: 31nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352933(CHEMBL1824919)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352932(CHEMBL1824920)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352942(CHEMBL1824910)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352941(CHEMBL1824911)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352931(CHEMBL1824921)
Affinity DataIC50: 48nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352946(CHEMBL1824906)
Affinity DataIC50: 49nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352940(CHEMBL1824912)
Affinity DataIC50: 63nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352945(CHEMBL1824907)
Affinity DataIC50: 79nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352939(CHEMBL1824913 | WO2022112139, Example 9)
Affinity DataIC50: 89nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352930(CHEMBL1824922)
Affinity DataIC50: 93nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352937(CHEMBL1824914)
Affinity DataIC50: 93nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50352938(CHEMBL1580265)
Affinity DataIC50: 109nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed