Compile Data Set for Download or QSAR
Report error Found 114 Enz. Inhib. hit(s) with all data for entry = 50040375
LigandPNGBDBM50393244(CHEMBL2151438)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity to human alpha7 nAchRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393252(CHEMBL2151570)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]A-585539 from alpha7 nAChR rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393252(CHEMBL2151570)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]A-585539 from alpha7 nAChR human cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393251(CHEMBL2151569)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50161758(2-(5-chloro-2,3-dihydrobenzo[b]furan-7-ylcarboxami...)
Affinity DataKi:  1nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50309873(4-(6-Chlorooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabi...)
Affinity DataKi:  1nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393247(CHEMBL1258006)
Affinity DataKi:  1nMAssay Description:Binding affinity to human alpha7 nAChR expressed in HEK293 cells co-expressing RIC3 cDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393247(CHEMBL1258006)
Affinity DataKi:  1nMAssay Description:Binding affinity to alpha7 nAChR in rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393253(CHEMBL2151573)
Affinity DataIC50: 1.09nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50190788(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataKi:  2nMAssay Description:Inhibition of 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393249(CHEMBL2151441)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-MLA from alpha7 nAChR in rat hippocampal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50190785(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzothioph...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at 5HT3 receptor expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393243(CHEMBL2151437)
Affinity DataKi:  3nMAssay Description:Binding affinity to human alpha7 nAchRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50309888(4-(6-Chloro-5-methyloxazolo[4,5-b]pyridin-2-yl)-1,...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393255(CHEMBL2151572)
Affinity DataKi:  4.30nMAssay Description:Binding affinity to human alpha7 nAchRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataKi:  6nMAssay Description:Binding affinity to human alpha7 nAChR expressed in HEK293 cells co-expressing RIC3 cDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataKi:  6nMAssay Description:Binding affinity to human alpha7 nAchRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  6.90nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393252(CHEMBL2151570)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-MLA from alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393253(CHEMBL2151573)
Affinity DataKi:  7.04nMAssay Description:Displacement of [125I]alpha-Bungarotoxin from alpha7 nAchR in mouse hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393242(CHEMBL2151444)
Affinity DataKi:  8.40nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50164618((2R)-3'-(5-chlorothien-2-yl)-2'H-spiro[4-azabicycl...)
Affinity DataKi:  9nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393241(CHEMBL2151445)
Affinity DataKi:  9.60nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50164963((4-Bromo-phenyl)-carbamic acid (2R,3R)-2-pyridin-3...)
Affinity DataKi:  10nMAssay Description:Binding affinity to alpha7 nAChR in rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-MLA from alpha7 nAChR in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50278956(cis-2-(6-Phenyl-pyridazin-3-yl)-5-methyloctahydro-...)
Affinity DataKi:  10.8nMAssay Description:Binding affinity to alpha7 nAChR in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393250(CHEMBL2151442)
Affinity DataKi:  11nMAssay Description:Binding affinity to alpha7 nAChR in rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataKi:  11nMAssay Description:Binding affinity to alpha7 nAChR in rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50393243(CHEMBL2151437)
Affinity DataKi:  12nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataKi:  12.5nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50309862(4-Benzoxazo-2-yl-1,4-diazabicyclo[3.2.2]nonane | C...)
Affinity DataKi:  13nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50149146((S)-3-(Benzo[b]thiophen-2-ylmethoxy)-1-aza-bicyclo...)
Affinity DataKi:  13nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human alpha7 nAchRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50278956(cis-2-(6-Phenyl-pyridazin-3-yl)-5-methyloctahydro-...)
Affinity DataKi:  17nMAssay Description:Binding affinity to alpha7 nAchR in human frontal cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataKi:  22nMAssay Description:Binding affinity to rat alpha7 nAchRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50309862(4-Benzoxazo-2-yl-1,4-diazabicyclo[3.2.2]nonane | C...)
Affinity DataKi:  22.5nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393256(CHEMBL2113232)
Affinity DataKi:  28nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50309868(4-Oxazolo[4,5-b]pyridin-2-yl-1,4-diazabicyclo[3.2....)
Affinity DataKi:  30.3nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataIC50: 32.7nMAssay Description:Antagonist activity at 5HT3 receptor expressed in N1E115 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393247(CHEMBL1258006)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50164959(US8541447, 4 | CHEMBL372419 | (4-Bromo-phenyl)-car...)
Affinity DataKi:  40nMAssay Description:Binding affinity to alpha7 nAChR in rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50190788(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataEC50:  43nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50190785(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzothioph...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataEC50:  50nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393252(CHEMBL2151570)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393252(CHEMBL2151570)
Affinity DataEC50:  50nMAssay Description:Agonist activity at rat alpha7 nAchR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50393246(CHEMBL2151440 | US9067931, 130 | US10214524, Examp...)
Affinity DataKi:  60nMAssay Description:Binding affinity to human recombinant 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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