Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50040974
TargetEpidermal growth factor receptor(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM4566(N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-y...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant Btk after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 0.700nMAssay Description:Irreversible inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 10(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50403056(CHEMBL2216827 | US9987276, Compound I-342 | US1059...)
Affinity DataIC50: 1nMAssay Description:Inhibition of BtkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50403056(CHEMBL2216827 | US9987276, Compound I-342 | US1059...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Btk in human Ramos cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50403057(CHEMBL2216828)
Affinity DataIC50: 2nMAssay Description:Inhibition of BtkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50403059(CHEMBL2216829 | US9505766, 64)
Affinity DataIC50: 4nMAssay Description:Inhibition of RSK2 transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataIC50: 5nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM4566(N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-y...)
Affinity DataIC50: 5nMAssay Description:Inhibition of EGF-induced autophosphorylation of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50403055(CHEMBL2216826)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 6nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50: 6nMAssay Description:Inhibition of GST-tagged EGFR expressed in sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of FGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of recombinant FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ErbB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 12nMAssay Description:Inhibition of FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 14nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50248765(1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...)
Affinity DataIC50: 15nMAssay Description:Inhibition of RSK2 transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 19nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM15234(NSC221019 | Wortmannin, Wm | cid_312145 | CHEMBL42...)
Affinity DataIC50: 24nMAssay Description:Inhibition of GST-tagged Plk1 using recombinant protein X as a substrate containing threonine residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 1(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50403055(CHEMBL2216826)
Affinity DataIC50: 31nMAssay Description:Inhibition of MEKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50: 46nMAssay Description:Inhibition of GST-tagged ErbB2 expressed in sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50: 74nMAssay Description:Inhibition of GST-tagged ErbB4 expressed in sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 80nMAssay Description:Inhibition of Erk2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50403054(CHEMBL2216825)
Affinity DataIC50: 149nMAssay Description:Inhibition of human AKT1 using biotinylated GSKalpha peptide (SGRARTSSFA) as a substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 189nMAssay Description:Inhibition of FGFR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 300nMAssay Description:Inhibition of MEK7More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM29508(Frenolicin B)
Affinity DataIC50: 313nMAssay Description:Inhibition of human AKT1 using biotinylated GSKalpha peptide (SGRARTSSFA) as a substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM15015(2-tert-Butyl 4-Ethyl 3-Ethyl-5-formyl-1H-pyrrole-2...)
Affinity DataIC50: 490nMAssay Description:Inhibition of IGF-1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MKK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50403061(CHEMBL2216823 | US9353116, 9)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of chicken c-Src using IYGEFKKK peptide as a substrate and [32P]ATP by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of chicken c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50307935((2R,3S)-N-(4-(3-Bromoanilino)quinazolin-6-yl)-3-(p...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of chicken c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM4566(N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-y...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of chicken c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of chicken c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)