Compile Data Set for Download or QSAR
Report error Found 50 Enz. Inhib. hit(s) with all data for entry = 50039960
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386885(CANAGLIFLOZIN HYDRATE | CANAGLIFLOZIN | US10752604...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386886(CHEMBL2048488)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386883(CHEMBL2048496)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386889(CHEMBL2048493)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386884(CHEMBL2048497)
Affinity DataIC50: 10nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386880(CHEMBL2048487)
Affinity DataIC50: 11nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386881(CHEMBL2048490)
Affinity DataIC50: 12nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386888(CHEMBL2048491)
Affinity DataIC50: 14nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20875(CHEMBL245067 | JMC511145 Compound 1 | 1-(2,4-dihyd...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386882(CHEMBL2048492)
Affinity DataIC50: 19nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386879(CHEMBL2048486)
Affinity DataIC50: 49nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386890(CHEMBL2048494)
Affinity DataIC50: 52nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386878(CHEMBL2048485)
Affinity DataIC50: 73nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386887(CHEMBL2048489)
Affinity DataIC50: 100nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386891(CHEMBL2048495)
Affinity DataIC50: 170nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20875(CHEMBL245067 | JMC511145 Compound 1 | 1-(2,4-dihyd...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50351429(CHEMBL450044)
Affinity DataIC50: 260nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386886(CHEMBL2048488)
Affinity DataIC50: 510nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataIC50: 800nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386885(CANAGLIFLOZIN HYDRATE | CANAGLIFLOZIN | US10752604...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386883(CHEMBL2048496)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386884(CHEMBL2048497)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50351429(CHEMBL450044)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386890(CHEMBL2048494)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386883(CHEMBL2048496)
Affinity DataIC50: 2.57E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture simultaneously with BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386880(CHEMBL2048487)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386884(CHEMBL2048497)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture simultaneously with BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386887(CHEMBL2048489)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386879(CHEMBL2048486)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386880(CHEMBL2048487)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture before addition of BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386882(CHEMBL2048492)
Affinity DataIC50: 3.66E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture simultaneously with BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386883(CHEMBL2048496)
Affinity DataIC50: 4.03E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture before addition of BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386878(CHEMBL2048485)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386881(CHEMBL2048490)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture simultaneously with BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386879(CHEMBL2048486)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture before addition of BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386878(CHEMBL2048485)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture before addition of BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386881(CHEMBL2048490)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture before addition of BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386882(CHEMBL2048492)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture before addition of BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386884(CHEMBL2048497)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture before addition of BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386879(CHEMBL2048486)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture simultaneously with BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386878(CHEMBL2048485)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture simultaneously with BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386881(CHEMBL2048490)
Affinity DataIC50: 7.30E+4nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386880(CHEMBL2048487)
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of CYP3A4 using BFC substrate in which compound added to reaction mixture simultaneously with BFC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386888(CHEMBL2048491)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386889(CHEMBL2048493)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386882(CHEMBL2048492)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386891(CHEMBL2048495)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed