Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50040521
TargetHistamine H1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Affinity DataIC50: 1.07nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM22567(CHEMBL511 | PYRILAMINE | 3H]pyrilamine | N-[2-(dim...)
Affinity DataIC50: 5.75nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM22567(CHEMBL511 | PYRILAMINE | 3H]pyrilamine | N-[2-(dim...)
Affinity DataIC50: 46.8nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50062614(Dimethyl-[2-(phenyl-o-tolyl-methoxy)-ethyl]-amine ...)
Affinity DataIC50: 162nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM67545(cid_5887 | PROMAZINE | SR-01000000228-4 | N,N-dime...)
Affinity DataIC50: 1.26E+3nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM67545(cid_5887 | PROMAZINE | SR-01000000228-4 | N,N-dime...)
Affinity DataIC50: 2.45E+3nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50062598(1-Cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-o...)
Affinity DataIC50: 6.76E+3nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataIC50: 1.12E+4nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataIC50: 1.26E+4nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395519(ADIPHENINE)
Affinity DataIC50: 1.70E+4nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50062598(1-Cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-o...)
Affinity DataIC50: 1.78E+4nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50008984(N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionami...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataIC50: 4.47E+4nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50062614(Dimethyl-[2-(phenyl-o-tolyl-methoxy)-ethyl]-amine ...)
Affinity DataIC50: 9.77E+4nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395519(ADIPHENINE)
Affinity DataIC50: 1.12E+5nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50008984(N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionami...)
Affinity DataIC50: 1.48E+5nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataIC50: 3.16E+5nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed