Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50001310
TargetDihydrofolate reductase(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity towards dihydrofolate reductase derived from human manca leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014707(CHEMBL431359 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataIC50: 40nMAssay Description:Inhibitory activity towards dihydrofolate reductase derived from human manca leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014706(CHEMBL302068 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataIC50: 70nMAssay Description:Inhibitory activity towards dihydrofolate reductase derived from human manca leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014707(CHEMBL431359 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Concentration inhibiting GAR transformylase enzyme of Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014707(CHEMBL431359 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Concentration inhibiting AICAR formyltransferase enzyme of Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014706(CHEMBL302068 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Concentration inhibiting AICAR formyltransferase enzyme of Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014706(CHEMBL302068 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration inhibiting thymidylate synthase enzyme of Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014707(CHEMBL431359 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration inhibiting thymidylate synthase enzyme of Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50016460(Edatrexate | GNF-Pf-63 | (S)-2-{4-[1-(2,4-Diamino-...)
Affinity DataKi:  0.00280nMAssay Description:Concentration inhibiting dihydrofolate reductase derived from L1210 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50010932(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoyl...)
Affinity DataKi:  0.00340nMAssay Description:Concentration inhibiting dihydrofolate reductase derived from L1210 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014707(CHEMBL431359 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataKi:  0.00520nMAssay Description:Concentration inhibiting dihydrofolate reductase derived from L1210 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014706(CHEMBL302068 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataKi:  0.00550nMAssay Description:Concentration inhibiting Dihydrofolate reductase derived from L1210 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50016460(Edatrexate | GNF-Pf-63 | (S)-2-{4-[1-(2,4-Diamino-...)
Affinity DataKi:  990nMAssay Description:Inhibitory activity towards Dihydrofolate reductase derived from human manca leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50010932(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoyl...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibitory activity towards Dihydrofolate reductase derived from human manca leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014707(CHEMBL431359 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity towards Dihydrofolate reductase derived from L1210 cells using [3H]- MTX as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataKi:  3.90E+3nMAssay Description:Inhibitory activity towards Dihydrofolate reductase derived from human manca leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataKi:  3.90E+3nMAssay Description:Binding affinity towards Dihydrofolate reductase derived from L1210 cells using [3H]- MTX as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Sri International

Curated by ChEMBL
LigandPNGBDBM50014706(CHEMBL302068 | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)...)
Affinity DataKi:  8.20E+3nMAssay Description:Inhibitory activity towards Dihydrofolate reductase derived from human manca leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed