Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50040716
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398811(CHEMBL2177507)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398808(CHEMBL2177506)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398810(CHEMBL2177509)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398809(CHEMBL2177510)
Affinity DataIC50: 55.9nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398808(CHEMBL2177506)
Affinity DataIC50: 89.4nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50106556(2-Phosphonomethyl-hexanedioic acid | CHEMBL334737)
Affinity DataIC50: 185nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17759(pentanedioic acid analogue, (S)-1 | (2S)-2-(phosph...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398811(CHEMBL2177507)
Affinity DataKi:  1.40nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398808(CHEMBL2177506)
Affinity DataKi:  2.60nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398810(CHEMBL2177509)
Affinity DataKi:  3.10nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50304731((S)-2-(3-((S)-1-Carboxy-2-(furan-2-yl)ethyl)ureido...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50304722((S)-2-(3-((S)-1-Carboxybut-3-ynyl)ureido)-6-(4-iod...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50102258((S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-...)
Affinity DataKi:  8nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50304751((S)-2-(3-((S)-1-Carboxybut-3-enyl)ureido)-6-(4-iod...)
Affinity DataKi:  11nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50304735((S)-2-(3-((S)-1-Carboxy-2-(thiazol-4-yl)ethyl)urei...)
Affinity DataKi:  16.1nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50304732((S)-2-(3-((S)-1-Carboxy-2-(thiophen-2-yl)ethyl)ure...)
Affinity DataKi:  16.2nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398809(CHEMBL2177510)
Affinity DataKi:  22nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50304727((S)-2-(3-((S)-1-Carboxy-3-(methylthio)propyl)ureid...)
Affinity DataKi:  23nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17758(pentanedioic acid analogue, (R)-1 | (2R)-2-(phosph...)
Affinity DataKi:  30nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398808(CHEMBL2177506)
Affinity DataKi:  36.4nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398812(CHEMBL2177511)
Affinity DataKi:  392nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50048693(2-Phosphonomethyl-succinic acid | 2-Phosphonomethy...)
Affinity DataKi:  700nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398813(CHEMBL2114987)
Affinity DataKi:  1.11E+3nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398814(CHEMBL2115435)
Affinity DataKi:  1.29E+3nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed