Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 50045937
TargetPOU domain, class 2, transcription factor 1(Human)
Nippon Boehringer Ingelheim

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of OCT1 (unknown origin) expressed in HEK293 cells assessed as reduction of [14C]metformin substrate uptake at 100 uM by liquid scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetPOU domain, class 2, transcription factor 1(Human)
Nippon Boehringer Ingelheim

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of OCT1 (unknown origin) expressed in HEK293 cells assessed as reduction of [ethyl 1-14C]TEA substrate uptake at 100 uM by liquid scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetPOU domain, class 2, transcription factor 2(Human)
Nippon Boehringer Ingelheim

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of OCT2 (unknown origin) expressed in HEK293 cells assessed as reduction of [14C]metformin substrate uptake at 100 uM by liquid scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Nippon Boehringer Ingelheim

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction of [3H]E-sul substrate uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member 1B1(Human)
Nippon Boehringer Ingelheim

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells assessed as reduction of [3H]E217betaG substrate uptake by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed