Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50045953
TargetMicrotubule-associated protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50088521(CHEMBL3527219)
Affinity DataEC50:  12nMAssay Description:Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetMicrotubule-associated protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50088522(CHEMBL3527218)
Affinity DataEC50:  8.80nMAssay Description:Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetMicrotubule-associated protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50088523(CHEMBL3527383)
Affinity DataEC50:  7.10nMAssay Description:Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetMicrotubule-associated protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50088524(CHEMBL3527328)
Affinity DataEC50:  6.5nMAssay Description:Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetMicrotubule-associated protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50088525(CHEMBL3526173)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetMicrotubule-associated protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50088526(CHEMBL3527591)
Affinity DataEC50:  0.300nMAssay Description:Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetMicrotubule-associated protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50088527(CHEMBL3527358)
Affinity DataEC50:  0.0950nMAssay Description:Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of CYP3A4 activity in human liver microsomes assessed as dibenzo fluuorescene oxidation up to 40 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataKi:  7nMAssay Description:Inhibition of CYP3A4 activity in human liver microsomes using midazolam as a substrate by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataKi:  11nMAssay Description:Inhibition of CYP3A4 activity in human liver microsomes using nifedipine as a substrate by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataKi:  49nMAssay Description:Inhibition of CYP3A4 activity in human liver microsomes using testosterone as a substrate by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50088527(CHEMBL3527358)
Affinity DataKi:  5.80E+4nMAssay Description:Inhibition of CYP3A4 activity in human liver microsomes using midazolam as a substrate by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50088527(CHEMBL3527358)
Affinity DataKi:  2.87E+5nMAssay Description:Inhibition of CYP3A4 activity in human liver microsomes using testosterone as a substrate by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50088527(CHEMBL3527358)
Affinity DataKi:  4.03E+5nMAssay Description:Inhibition of CYP3A4 activity in human liver microsomes using nifedipine as a substrate by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed