Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50043125
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human N-terminal GST-tagged LRRK2 after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50436423(CHEMBL2397014)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant wild type LRRK2 using biotin-LRRKtide as substrate preincubated for 15 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM482157(LRRK2-IN-1 | BDBM50379529 | US11370796, Compound L...)
Affinity DataIC50: 13nMAssay Description:Inhibition of wild type GST-tagged LRRK2 ((1326 to 2517 amino acids) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human N-terminal GST-tagged LRRK2 after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50132420(CHEMBL2397013 | CHEMBL323994 | 3-((1H-pyrrol-2-yl)...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human N-terminal GST-tagged LRRK2 after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM14028(H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...)
Affinity DataIC50: 244nMAssay Description:Inhibition of human N-terminal GST-tagged LRRK2 after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed