Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50005556
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50358775(CHEMBL1922641)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at 5-HT6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50134807(3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]py...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492797(CHEMBL2413990)
Affinity DataKi:  0.160nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492792(CHEMBL2413982)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-lysergic acid diethylamide from human 5-HT6 receptor expressed in HEK293 cell membranes after 3.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50318633(SB-742457 | 3-benzenesulfonyl-8-piperazin-1-ylquin...)
Affinity DataKi:  0.230nMAssay Description:Antagonist activity at 5-HT6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50314763(US8629154, 2(2) | CHEMBL1092241 | 9-methyl-2-(meth...)
Affinity DataKi:  0.680nMAssay Description:Antagonist activity at 5-HT6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50419052(SB-399885)
Affinity DataKi:  0.800nMAssay Description:Antagonist activity at 5-HT6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492786(CHEMBL2413989)
Affinity DataKi:  1.70nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492785(CHEMBL2413991)
Affinity DataKi:  8.30nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50193458(4-(4-benzenesulfonylphenyl)piperazine | CHEMBL2115...)
Affinity DataKi:  11nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492796(CHEMBL2413985)
Affinity DataKi:  24nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492790(CHEMBL2413988)
Affinity DataKi:  30nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492794(CHEMBL2413986)
Affinity DataKi:  48nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492793(CHEMBL2413987)
Affinity DataKi:  153nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50029764(p-aminophenyl sulfone | 1,1'-sulfonylbis(4-aminobe...)
Affinity DataKi:  183nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492789(CHEMBL2009408)
Affinity DataKi:  491nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492787(CHEMBL1581846)
Affinity DataKi:  564nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492795(CHEMBL2413984)
Affinity DataKi:  866nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492788(CHEBI:78360 | 1-(Phenylsulfonyl)Benzene | (PHENYLS...)
Affinity DataKi:  1.60E+3nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50492791(CHEMBL2413983)
Affinity DataKi:  2.04E+3nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed