Compile Data Set for Download or QSAR
Report error Found 79 Enz. Inhib. hit(s) with all data for entry = 50043379
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50437098(CHEMBL2403658)
Affinity DataEC50:  123nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440189(CHEMBL2426614)
Affinity DataEC50:  1.75E+3nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50187649((S)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-[1,2,...)
Affinity DataEC50:  199nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50156071(3-Cyano-N-(2,5-diphenyl-2H-pyrazol-3-yl)-benzamide...)
Affinity DataEC50:  176nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440206(CHEMBL2426613)
Affinity DataEC50:  119nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50437097(CHEMBL2403659)
Affinity DataEC50:  193nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM49388(7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one | SMR00...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu3 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440205(CHEMBL2426621)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50337525(7-(phenoxymethyl)chroman-4-one | CHEMBL1682820)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM49388(7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one | SMR00...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440190(CHEMBL2426615)
Affinity DataEC50:  1.13E+3nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440185(CHEMBL2426616)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440205(CHEMBL2426621)
Affinity DataEC50:  33nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50337500(7-(phenylethynyl)chroman-4-one | CHEMBL1682796)
Affinity DataEC50:  682nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50337525(7-(phenoxymethyl)chroman-4-one | CHEMBL1682820)
Affinity DataEC50:  2.14E+3nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM49388(7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one | SMR00...)
Affinity DataEC50:  950nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50337526(4-oxochroman-7-yl benzoate | CHEMBL1682821)
Affinity DataEC50:  128nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50337526(4-oxochroman-7-yl benzoate | CHEMBL1682821)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440205(CHEMBL2426621)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50337525(7-(phenoxymethyl)chroman-4-one | CHEMBL1682820)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50337526(4-oxochroman-7-yl benzoate | CHEMBL1682821)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440203(CHEMBL2426606)
Affinity DataEC50:  77nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440202(CHEMBL2426605)
Affinity DataEC50:  553nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440201(CHEMBL2426604)
Affinity DataEC50:  66nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440205(CHEMBL2426621)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50337525(7-(phenoxymethyl)chroman-4-one | CHEMBL1682820)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440200(CHEMBL2426603)
Affinity DataEC50:  96nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440199(CHEMBL2426602)
Affinity DataEC50:  851nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM49388(7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one | SMR00...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440198(CHEMBL2426601)
Affinity DataEC50:  250nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM49388(7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one | SMR00...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440197(CHEMBL2426620)
Affinity DataEC50:  1.46E+3nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440196(CHEMBL2426619)
Affinity DataEC50:  2.31E+3nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440195(CHEMBL2426618)
Affinity DataEC50:  1.21E+3nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440204(CHEMBL2426607)
Affinity DataEC50:  739nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440205(CHEMBL2426621)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50337525(7-(phenoxymethyl)chroman-4-one | CHEMBL1682820)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM49388(7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one | SMR00...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440205(CHEMBL2426621)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu3 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50337525(7-(phenoxymethyl)chroman-4-one | CHEMBL1682820)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu3 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440190(CHEMBL2426615)
Affinity DataEC50:  1.12E+3nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440197(CHEMBL2426620)
Affinity DataEC50:  1.45E+3nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440196(CHEMBL2426619)
Affinity DataEC50:  2.29E+3nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440195(CHEMBL2426618)
Affinity DataEC50:  1.20E+3nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440194(CHEMBL2426612)
Affinity DataEC50:  791nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440185(CHEMBL2426616)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440193(CHEMBL2426617)
Affinity DataEC50:  692nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440185(CHEMBL2426616)
Affinity DataEC50:  1.20E+3nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440192(CHEMBL2426611)
Affinity DataEC50:  621nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50440191(CHEMBL2426610)
Affinity DataEC50:  2.69E+3nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
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