Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 7747
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Vanderbilt University

LigandPNGBDBM213825(VNI)
Affinity DataKd:  15nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetPutative lanosterol 14-alpha-demethylase(Leishmania infantum)
Vanderbilt University

LigandPNGBDBM213824(Posaconazole)
Affinity DataKd:  18nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Vanderbilt University

LigandPNGBDBM213824(Posaconazole)
Affinity DataKd:  18nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataKd:  19nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM213822(EPL-BS0967 (UDD))
Affinity DataKd:  26nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Vanderbilt University

LigandPNGBDBM213822(EPL-BS0967 (UDD))
Affinity DataKd:  32nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataKd:  69nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetPutative lanosterol 14-alpha-demethylase(Leishmania infantum)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataKd:  156nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetPutative lanosterol 14-alpha-demethylase(Leishmania infantum)
Vanderbilt University

LigandPNGBDBM213822(EPL-BS0967 (UDD))
Affinity DataKd:  419nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataIC50: 4.00E+3nMT: 2°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University

LigandPNGBDBM213822(EPL-BS0967 (UDD))
Affinity DataIC50: 8.10E+3nMT: 2°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataIC50: 9.00E+3nMT: 2°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Vanderbilt University

LigandPNGBDBM213822(EPL-BS0967 (UDD))
Affinity DataIC50: 9.80E+3nMT: 2°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataIC50: 1.20E+4nMT: 2°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University

LigandPNGBDBM213822(EPL-BS0967 (UDD))
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University

LigandPNGBDBM213822(EPL-BS0967 (UDD))
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University

LigandPNGBDBM213822(EPL-BS0967 (UDD))
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed