Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50043443
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50156071(3-Cyano-N-(2,5-diphenyl-2H-pyrazol-3-yl)-benzamide...)
Affinity DataEC50:  27nMAssay Description:Positive allosteric modulation of human mGluR5 stably expressed in CHO cells assessed as Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50441230(CHEMBL2431212)
Affinity DataEC50:  33nMAssay Description:Positive allosteric modulation of human mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50441231(CHEMBL2431211)
Affinity DataEC50:  52nMAssay Description:Positive allosteric modulation of human mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50156070(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of human mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50187649((S)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-[1,2,...)
Affinity DataEC50:  157nMAssay Description:Positive allosteric modulation of human mGluR5 stably expressed in HEK293 cells assessed as Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50331975(1-(4-(2-chloro-4-fluorophenyl)piperazin-1-yl)-2-(p...)
Affinity DataEC50:  550nMAssay Description:Positive allosteric modulation of human mGluR5 over-expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50156074(N,N''-Bis-[1-(3-fluoro-phenyl)-meth-(E)-ylidene]-h...)
Affinity DataEC50:  2.60E+3nMAssay Description:Positive allosteric modulation of mGluR5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50441232(CHEMBL2431173)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50441232(CHEMBL2431173)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50441232(CHEMBL2431173)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed