Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 7751
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataIC50: 34nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataIC50: 160nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2A(Rat)
University of Copenhagen

LigandPNGBDBM213889(5,7-Dichlorokynurenic acid (5,7-DCKA))
Affinity DataKi:  65nM ΔG°:  -41.0kJ/mole IC50: 92nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataKi: >300nM ΔG°: >-37.2kJ/mole IC50: 3.00E+3nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2A(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataKi:  560nM ΔG°:  -35.7kJ/mole IC50: 770nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataKi: >800nM ΔG°: >-34.8kJ/mole IC50: 3.00E+3nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataKi: >1.30E+3nM ΔG°: >-33.6kJ/mole IC50: 3.00E+3nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM213889(5,7-Dichlorokynurenic acid (5,7-DCKA))
Affinity DataKi:  3.50E+4nM ΔG°:  -25.4kJ/mole IC50: 9.70E+4nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
LigandPNGBDBM213889(5,7-Dichlorokynurenic acid (5,7-DCKA))
Affinity DataKi: >1.50E+5nM ΔG°: >-21.8kJ/mole IC50: 3.00E+5nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataKi: >1.80E+5nM ΔG°: >-21.4kJ/mole IC50: 3.00E+5nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed