Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50043589
TargetALK tyrosine kinase receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of ALK (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 30 mins followed by NADPH and substrate addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 30 mins post NADPH addition followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes incubated for 30 mins post NADPH addition measured after 5 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 30 mins followed by NADPH addition measured after 5 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK-1 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK-2 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FLT3 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of AXL (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of RON (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MET (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of DDR1 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ABL (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of InsR (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FAK (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of BRK (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes preincubated for 30 mins followed by NADPH addition measured after 5 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 30 mins followed by NADPH addition measured after 5 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes incubated for 30 mins post NADPH addition measured after 5 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 in human liver microsomes incubated for 30 mins post NADPH addition measured after 5 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed