Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 6079
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 42nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 114nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107675(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(2- me...)
Affinity DataIC50: 142nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107677(1-(3-Chloro-4-fluorophenyl)-3-(3-(methyl (2-methyl...)
Affinity DataIC50: 232nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107675(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(2- me...)
Affinity DataIC50: 271nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107673(1-(3-(6-Chloro-2-methylpyrimidin-4-ylamino)phenyl)...)
Affinity DataIC50: 298nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107677(1-(3-Chloro-4-fluorophenyl)-3-(3-(methyl (2-methyl...)
Affinity DataIC50: 366nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107674(1-(3-Chloro-4-fluorophenyl)-3-(3-(2-methyl- 6-morp...)
Affinity DataIC50: 626nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107673(1-(3-(6-Chloro-2-methylpyrimidin-4-ylamino)phenyl)...)
Affinity DataIC50: 722nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107674(1-(3-Chloro-4-fluorophenyl)-3-(3-(2-methyl- 6-morp...)
Affinity DataIC50: 1.07E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107678(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methy...)
Affinity DataIC50: 1.37E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107678(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methy...)
Affinity DataIC50: 1.37E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107679(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methy...)
Affinity DataIC50: 4.99E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107679(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methy...)
Affinity DataIC50: 5.28E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107676(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(2- me...)
Affinity DataIC50: 7.17E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107676(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(2- me...)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed