Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50043752
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50157555(2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 3',4'-d...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50077325(7,3',4'-Trihydroxyflavone | 2-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50445691(CHEMBL243677)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50445691(CHEMBL243677)
Affinity DataKi:  1.80E+4nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7461(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | cid_5281...)
Affinity DataKi:  1.94E+4nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50157555(2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 3',4'-d...)
Affinity DataKi:  8.45E+4nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50445690(CHEMBL457821)
Affinity DataKi:  9.54E+4nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50312650(5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 5...)
Affinity DataKi:  1.03E+5nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataKi:  1.07E+5nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataKi:  1.22E+5nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7458(Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataKi:  1.78E+5nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed