Compile Data Set for Download or QSAR
Report error Found 185 Enz. Inhib. hit(s) with all data for entry = 50044112
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003868(CHEMBL3235353)
Affinity DataIC50: 6nMAssay Description:Inhibition of HSP90 in Huntington's disease patient derived fibroblasts assessed as reduction of mHtt level after 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of HSP90 in Huntington's disease patient derived fibroblasts assessed as reduction of mHtt level after 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003870(CHEMBL3235355)
Affinity DataIC50: 19nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003868(CHEMBL3235353)
Affinity DataIC50: 24nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003900(CHEMBL3235350)
Affinity DataIC50: 27nMAssay Description:Inhibition of HSP90 in Huntington's disease patient derived fibroblasts assessed as reduction of mHtt level after 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50445478(CHEMBL3104858)
Affinity DataIC50: 30nMAssay Description:Inhibition of HSP90 in Huntington's disease patient derived fibroblasts assessed as reduction of mHtt level after 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003869(CHEMBL3235354)
Affinity DataIC50: 36nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003894(CHEMBL3235345)
Affinity DataIC50: 73nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003877(CHEMBL3235361)
Affinity DataIC50: 80nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003878(CHEMBL3235362)
Affinity DataIC50: 81nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003887(CHEMBL3235338)
Affinity DataIC50: 90nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003884(CHEMBL3235335)
Affinity DataIC50: 110nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003881(CHEMBL3235333)
Affinity DataIC50: 120nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003883(CHEMBL3235334)
Affinity DataIC50: 120nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003892(CHEMBL3235343)
Affinity DataIC50: 140nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003900(CHEMBL3235350)
Affinity DataIC50: 143nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003885(CHEMBL3235336)
Affinity DataIC50: 190nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003888(CHEMBL3235339)
Affinity DataIC50: 190nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003871(CHEMBL3235356)
Affinity DataIC50: 195nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003890(CHEMBL3235341)
Affinity DataIC50: 220nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003865(CHEMBL3235352)
Affinity DataIC50: 222nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003876(CHEMBL3235360)
Affinity DataIC50: 230nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003880(CHEMBL3235363)
Affinity DataIC50: 280nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003889(CHEMBL3235340)
Affinity DataIC50: 420nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003891(CHEMBL3235342)
Affinity DataIC50: 450nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003875(CHEMBL3235359)
Affinity DataIC50: 480nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003901(CHEMBL3235351)
Affinity DataIC50: 530nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003886(CHEMBL3235337)
Affinity DataIC50: 720nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003893(CHEMBL3235344)
Affinity DataIC50: 930nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003872(CHEMBL3235357)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003873(CHEMBL3235358)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003899(CHEMBL3235349)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003897(CHEMBL3235347)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003895(CHEMBL3235346)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003898(CHEMBL3235348)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HSP90 in HEK cells expressing full-length mHtt Q73 gene assessed as reduction of mHtt level after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003870(CHEMBL3235355)
Affinity DataKi:  3nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003870(CHEMBL3235355)
Affinity DataKi:  3nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90alpha (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003868(CHEMBL3235353)
Affinity DataKi:  5nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003869(CHEMBL3235354)
Affinity DataKi:  5nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003868(CHEMBL3235353)
Affinity DataKi:  5nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90alpha (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003869(CHEMBL3235354)
Affinity DataKi:  6nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90alpha (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003877(CHEMBL3235361)
Affinity DataKi:  10nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003877(CHEMBL3235361)
Affinity DataKi:  10nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90alpha (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003884(CHEMBL3235335)
Affinity DataKi:  12nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003884(CHEMBL3235335)
Affinity DataKi:  14nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90alpha (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003876(CHEMBL3235360)
Affinity DataKi:  14nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90alpha (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003876(CHEMBL3235360)
Affinity DataKi:  15nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003885(CHEMBL3235336)
Affinity DataKi:  17nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90alpha (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003885(CHEMBL3235336)
Affinity DataKi:  19nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003878(CHEMBL3235362)
Affinity DataKi:  20nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
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