Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 6181
TargetFatty-acid amide hydrolase 1(Human)
University of Bern

LigandPNGBDBM26739(URB 597 | URB597 | CHEMBL184238 | 3-(3-carbamoylph...)
Affinity DataIC50: 1.20nMpH: 7.6 T: 2°CAssay Description:In this assay, 0.05 Units of hFAAH was pre-incubated for 30 min at 37 C with 2 uL of 11a, 11b, 11f at different concentrations (0.01 - 100 uM) or veh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM50029600(CHEMBL42485 | 5-bromo-2-(4-fluorophenyl)-3-(4-(met...)
Affinity DataIC50: 68nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM50029600(CHEMBL42485 | 5-bromo-2-(4-fluorophenyl)-3-(4-(met...)
Affinity DataIC50: 71nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113768((E)-N-(3,4-Dihydroxyphenethyl)-6-((1R,2R)-3,3-dime...)
Affinity DataIC50: 800nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113767((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataIC50: 2.20E+3nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Bern

LigandPNGBDBM113765((E)-N-Allyl-6-((1R,2R)-3,3-dimethyl-2-(3-methylbut...)
Affinity DataIC50: 2.70E+3nMpH: 7.6 T: 2°CAssay Description:In this assay, 0.05 Units of hFAAH was pre-incubated for 30 min at 37 C with 2 uL of 11a, 11b, 11f at different concentrations (0.01 - 100 uM) or veh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Bern

LigandPNGBDBM113764((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataIC50: 6.30E+3nMpH: 7.6 T: 2°CAssay Description:In this assay, 0.05 Units of hFAAH was pre-incubated for 30 min at 37 C with 2 uL of 11a, 11b, 11f at different concentrations (0.01 - 100 uM) or veh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Bern

LigandPNGBDBM113767((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataIC50: 7.10E+3nMpH: 7.6 T: 2°CAssay Description:In this assay, 0.05 Units of hFAAH was pre-incubated for 30 min at 37 C with 2 uL of 11a, 11b, 11f at different concentrations (0.01 - 100 uM) or veh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113768((E)-N-(3,4-Dihydroxyphenethyl)-6-((1R,2R)-3,3-dime...)
Affinity DataIC50: 8.90E+3nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Bern

LigandPNGBDBM113766((E)-N-(2-Chloroethyl)-6-((1R,2R)-3,3-dimethyl-2-(3...)
Affinity DataIC50: 1.00E+4nMpH: 7.6 T: 2°CAssay Description:In this assay, 0.05 Units of hFAAH was pre-incubated for 30 min at 37 C with 2 uL of 11a, 11b, 11f at different concentrations (0.01 - 100 uM) or veh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Bern

LigandPNGBDBM113768((E)-N-(3,4-Dihydroxyphenethyl)-6-((1R,2R)-3,3-dime...)
Affinity DataIC50: 1.00E+4nMpH: 7.6 T: 2°CAssay Description:In this assay, 0.05 Units of hFAAH was pre-incubated for 30 min at 37 C with 2 uL of 11a, 11b, 11f at different concentrations (0.01 - 100 uM) or veh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Bern

LigandPNGBDBM113763(β-humulene | (−)-trans-caryophyllene | ...)
Affinity DataIC50: 1.00E+4nMpH: 7.6 T: 2°CAssay Description:In this assay, 0.05 Units of hFAAH was pre-incubated for 30 min at 37 C with 2 uL of 11a, 11b, 11f at different concentrations (0.01 - 100 uM) or veh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113767((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataIC50: 1.45E+4nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113766((E)-N-(2-Chloroethyl)-6-((1R,2R)-3,3-dimethyl-2-(3...)
Affinity DataIC50: 5.00E+4nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113765((E)-N-Allyl-6-((1R,2R)-3,3-dimethyl-2-(3-methylbut...)
Affinity DataIC50: 5.00E+4nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113764((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataIC50: 5.00E+4nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113763(β-humulene | (−)-trans-caryophyllene | ...)
Affinity DataIC50: 5.00E+4nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113766((E)-N-(2-Chloroethyl)-6-((1R,2R)-3,3-dimethyl-2-(3...)
Affinity DataIC50: 5.00E+4nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113763(β-humulene | (−)-trans-caryophyllene | ...)
Affinity DataIC50: 5.00E+4nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113764((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataIC50: 5.00E+4nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113765((E)-N-Allyl-6-((1R,2R)-3,3-dimethyl-2-(3-methylbut...)
Affinity DataIC50: 5.00E+4nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Bern

LigandPNGBDBM21281(WIN55212-2 | CHEMBL188 | (2,3-dihydro-5-methyl-3-(...)
Affinity DataKi:  0.450nM ΔG°:  -54.2kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
University of Bern

LigandPNGBDBM21281(WIN55212-2 | CHEMBL188 | (2,3-dihydro-5-methyl-3-(...)
Affinity DataKi:  7.5nM ΔG°:  -47.2kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Bern

LigandPNGBDBM50180036(CHEMBL371214 | (6aR,10aR)-3-(1,1-dimethylbutyl)-6a...)
Affinity DataKi:  13nM ΔG°:  -45.8kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Bern

LigandPNGBDBM113765((E)-N-Allyl-6-((1R,2R)-3,3-dimethyl-2-(3-methylbut...)
Affinity DataKi:  680nM ΔG°:  -35.8kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Bern

LigandPNGBDBM113764((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataKi:  1.01E+3nM ΔG°:  -34.8kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Bern

LigandPNGBDBM113766((E)-N-(2-Chloroethyl)-6-((1R,2R)-3,3-dimethyl-2-(3...)
Affinity DataKi:  1.43E+3nM ΔG°:  -33.9kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Bern

LigandPNGBDBM113764((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataKi:  3.66E+3nM ΔG°:  -31.6kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Bern

LigandPNGBDBM113766((E)-N-(2-Chloroethyl)-6-((1R,2R)-3,3-dimethyl-2-(3...)
Affinity DataKi:  3.83E+3nM ΔG°:  -31.4kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Bern

LigandPNGBDBM113768((E)-N-(3,4-Dihydroxyphenethyl)-6-((1R,2R)-3,3-dime...)
Affinity DataKi:  6.50E+3nM ΔG°:  -30.1kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Bern

LigandPNGBDBM113765((E)-N-Allyl-6-((1R,2R)-3,3-dimethyl-2-(3-methylbut...)
Affinity DataKi:  8.64E+3nM ΔG°:  -29.4kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Bern

LigandPNGBDBM113768((E)-N-(3,4-Dihydroxyphenethyl)-6-((1R,2R)-3,3-dime...)
Affinity DataKi: >1.00E+4nM ΔG°: >-29.0kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Bern

LigandPNGBDBM113767((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataKi: >1.00E+4nM ΔG°: >-29.0kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Bern

LigandPNGBDBM113763(β-humulene | (−)-trans-caryophyllene | ...)
Affinity DataKi: >1.00E+4nM ΔG°: >-29.0kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Bern

LigandPNGBDBM113767((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataKi: >1.00E+4nM ΔG°: >-29.0kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed