Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50045299
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50: 3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of C-Raf (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 12nMAssay Description:Inhibition of B-Raf (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50055864(CHEMBL3326099)
Affinity DataIC50: 130nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50055864(CHEMBL3326099)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FLT3 (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50055864(CHEMBL3326099)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50055864(CHEMBL3326099)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of KIT (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50055864(CHEMBL3326099)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-Raf (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50055864(CHEMBL3326099)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of B-Raf (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50055864(CHEMBL3326099)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mTOR (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50055864(CHEMBL3326099)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KDR (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50055864(CHEMBL3326099)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50055864(CHEMBL3326099)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed