Compile Data Set for Download or QSAR
Report error Found 62 Enz. Inhib. hit(s) with all data for entry = 50044826
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031627(CHEMBL3359749)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031628(CHEMBL3359748)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031613(CHEMBL3359763)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031629(CHEMBL3359747)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031614(CHEMBL3359758)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031619(CHEMBL3359757)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031621(CHEMBL3359755)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031615(CHEMBL3359762)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031623(CHEMBL3359753)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031624(CHEMBL3359752)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031625(CHEMBL3359751)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031618(CHEMBL3359759)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031627(CHEMBL3359749)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031616(CHEMBL3359761)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031620(CHEMBL3359756)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031628(CHEMBL3359748)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031613(CHEMBL3359763)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031629(CHEMBL3359747)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031617(CHEMBL3359760)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031616(CHEMBL3359761)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031617(CHEMBL3359760)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031613(CHEMBL3359763)
Affinity DataIC50: 5nMAssay Description:Inhibition of BACE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031623(CHEMBL3359753)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031624(CHEMBL3359752)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031615(CHEMBL3359762)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031622(CHEMBL3359754)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031621(CHEMBL3359755)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031625(CHEMBL3359751)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031614(CHEMBL3359758)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031619(CHEMBL3359757)
Affinity DataIC50: 14nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031618(CHEMBL3359759)
Affinity DataIC50: 15nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 15nMAssay Description:Inhibition of BACE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031620(CHEMBL3359756)
Affinity DataIC50: 16nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031622(CHEMBL3359754)
Affinity DataIC50: 19nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 25nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031626(CHEMBL3359750)
Affinity DataIC50: 248nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetCathepsin E(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 320nMAssay Description:Inhibition of cathepsin E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetRenin(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031613(CHEMBL3359763)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetCathepsin E(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031613(CHEMBL3359763)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of cathepsin E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031626(CHEMBL3359750)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031613(CHEMBL3359763)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetRenin(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50031614(CHEMBL3359758)
Affinity DataKi:  210nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells assessed as [3H]-dofetilide binding after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataKi:  660nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells assessed as [3H]-dofetilide binding after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50031617(CHEMBL3359760)
Affinity DataKi:  1.16E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells assessed as [3H]-dofetilide binding after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50031619(CHEMBL3359757)
Affinity DataKi:  1.24E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells assessed as [3H]-dofetilide binding after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50031625(CHEMBL3359751)
Affinity DataKi:  2.95E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells assessed as [3H]-dofetilide binding after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50031627(CHEMBL3359749)
Affinity DataKi:  2.95E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells assessed as [3H]-dofetilide binding after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
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