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Report error Found 93 Enz. Inhib. hit(s) with all data for entry = 50044830
TargetTyrosine-protein kinase JAK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031743(CHEMBL3360349)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031745(CHEMBL3360351 | US10206907, Compound 225)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031760(CHEMBL3360330)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031744(CHEMBL3360350)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031738(CHEMBL3360355)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031742(CHEMBL3360348 | US10206907, Compound 59)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103737(US8563545, 11 | US10206907, Compound 234 | US11000...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031804(CHEMBL3360341)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetJak1 protein(Rat)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 29nMAssay Description:Inhibition of rat JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031740(CHEMBL3360357 | US10206907, Compound 304)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031806(CHEMBL3360343)
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031747(CHEMBL3360318)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 74nMAssay Description:Inhibition of JAK1 in human whole blood assessed as inhibition of IL-6-induced pSTAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 92nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031802(CHEMBL3360339 | US10206907, Compound 14)
Affinity DataIC50: 103nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031747(CHEMBL3360318)
Affinity DataIC50: 138nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50438696(CHEMBL2414557)
Affinity DataIC50: 142nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031746(CHEMBL3360352)
Affinity DataIC50: 147nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50438695(CHEMBL2414558)
Affinity DataIC50: 156nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031762(CHEMBL3360332)
Affinity DataIC50: 184nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 274nMAssay Description:Inhibition of human FLT4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031737(CHEMBL3360840)
Affinity DataIC50: 307nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 338nMAssay Description:Inhibition of human FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031763(CHEMBL3360333)
Affinity DataIC50: 371nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031758(CHEMBL3360328)
Affinity DataIC50: 413nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031807(CHEMBL3360344)
Affinity DataIC50: 418nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 489nMAssay Description:Inhibition of human CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031747(CHEMBL3360318)
Affinity DataIC50: 519nMAssay Description:Inhibition of human recombinant TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031747(CHEMBL3360318)
Affinity DataIC50: 528nMAssay Description:Inhibition of human recombinant JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031765(CHEMBL3360335)
Affinity DataIC50: 547nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031768(CHEMBL3360338)
Affinity DataIC50: 572nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 629nMAssay Description:Inhibition of JAK1 in human whole blood assessed as inhibition of IL-6-induced pSTAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 740nMAssay Description:Inhibition of JAK2 in human whole blood assessed as inhibition of GM-CSF-induced pSTAT5More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031766(CHEMBL3360336)
Affinity DataIC50: 975nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of JAK1 in human whole blood assessed as inhibition of IL-6-induced pSTAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031767(CHEMBL3360337)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031761(CHEMBL3360331)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031747(CHEMBL3360318)
Affinity DataIC50: 2.27E+3nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031764(CHEMBL3360334)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103737(US8563545, 11 | US10206907, Compound 234 | US11000...)
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibition of JAK1 in human whole blood assessed as inhibition of IL-6-induced pSTAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031805(CHEMBL3360342)
Affinity DataIC50: 3.01E+3nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031748(CHEMBL3360319)
Affinity DataIC50: 3.06E+3nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031741(CHEMBL3360347)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031747(CHEMBL3360318)
Affinity DataIC50: 3.18E+3nMAssay Description:Inhibition of PYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 3.52E+3nMAssay Description:Inhibition of JAK2 in IL3-induced human TF1 cells assessed as pSTAT5More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
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