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Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50022583
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652948(CHEMBL3597011)
Affinity DataIC50: 1nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652943(CHEMBL5687042)
Affinity DataIC50: 1nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652945(CHEMBL5687026)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataKd:  2.70nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant PAK4 (300 to 591 residues) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataKi:  3.30nMAssay Description:Inhibition of human recombinant PAK4 assessed as inhibition constant incubated for 10 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataKi:  3.30nMAssay Description:Inhibition of human recombinant PAK4 using KKRNRRLSVA as substrate assessed as inhibition constant preincubated with compound for 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Mus musculus)
Genentech

Curated by ChEMBL
LigandPNGBDBM50389121(CHEMBL2064628)
Affinity DataEC50:  4nMAssay Description:Inhibition of PAK4 in mouse NIH3T3 cells assessed as reduction in phosphorylated GEF-H1 accumulation incubated for 30 mins by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652947(CHEMBL5687057)
Affinity DataIC50: 4nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50097131(CHEMBL3580667)
Affinity DataKi:  4nMAssay Description:Inhibition of PAK4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652950(CHEMBL5687053)
Affinity DataIC50: 5nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50389111(CHEMBL2064555)
Affinity DataKi:  6nMAssay Description:Inhibition of PAK4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 7nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of PAK1 (unknown origin) in presence of ATP by Z-LYTE enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 8nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652946(CHEMBL5687023)
Affinity DataIC50: 8nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652949(CHEMBL5687001)
Affinity DataIC50: 10nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Mus musculus)
Genentech

Curated by ChEMBL
LigandPNGBDBM50389111(CHEMBL2064555)
Affinity DataEC50:  13nMAssay Description:Inhibition of PAK4 in mouse NIH3T3 cells assessed as reduction in phosphorylated GEF-H1 accumulation incubated for 30 mins by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataKi:  14nMAssay Description:Inhibition of recombinant PAK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 14nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 19nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652952(CHEMBL5686987)
Affinity DataIC50: 20nMAssay Description:Inhibition of PAK1 (unknown origin) using 5-FAM-KPDRKKRYTVVGNPY-amide as substrate incubated for 120 mins by caliper off-chip mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM213235(FRAX414)
Affinity DataIC50: 20nMAssay Description:Inhibition of PAK1 (unknown origin) in presence of ATP by Z-LYTE enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50148931(CHEMBL3770186)
Affinity DataKi:  23nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50389113(CHEMBL2064558)
Affinity DataKi:  30nMAssay Description:Inhibition of PAK4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Mus musculus)
Genentech

Curated by ChEMBL
LigandPNGBDBM50389113(CHEMBL2064558)
Affinity DataEC50:  32nMAssay Description:Inhibition of PAK4 in mouse NIH3T3 cells assessed as reduction in phosphorylated GEF-H1 accumulation incubated for 30 mins by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50448775(CHEMBL3128055)
Affinity DataKi:  60nMAssay Description:Inhibition of human recombinant PAK4 assessed as inhibition constant incubated for 10 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50389109(CHEMBL2064557)
Affinity DataKi:  64nMAssay Description:Inhibition of PAK4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652944(CHEMBL3596912)
Affinity DataIC50: 64nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50448780(CHEMBL3128050)
Affinity DataKi:  68nMAssay Description:Inhibition of human recombinant PAK4 assessed as inhibition constant incubated for 10 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50448780(CHEMBL3128050)
Affinity DataKi:  68nMAssay Description:Inhibition of human recombinant PAK4 using KKRNRRLSVA as substrate assessed as inhibition constant preincubated with compound for 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50389121(CHEMBL2064628)
Affinity DataKi:  75nMAssay Description:Inhibition of PAK4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 3(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 99nMAssay Description:Inhibition of recombinant PAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant PAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112351(CHEMBL3609330)
Affinity DataIC50: 340nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652950(CHEMBL5687053)
Affinity DataKd:  400nMAssay Description:Binding affinity to PAK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM6276(Pyrido[2,3-d]pyrimidin-7-one 1 | 8-Cyclopentyl-2-[...)
Affinity DataIC50: 483nMAssay Description:Inhibition of PAK1 (unknown origin) in presence of ATP by Z-LYTE enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataKi:  500nMAssay Description:Inhibition of GST-tagged PAK4 (291 to 591 residues) (unknown origin) expressed in HEK293 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50448770(CHEMBL3128044)
Affinity DataKi:  500nMAssay Description:Inhibition of human recombinant PAK4 using KKRNRRLSVA as substrate assessed as inhibition constant preincubated with compound for 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652952(CHEMBL5686987)
Affinity DataIC50: 550nMAssay Description:Inhibition of PAK4 (unknown origin) using 5-FAM-AhxKKRNRRLSVA-amide as substrate incubated for 90 mins by caliper off-chip mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM213235(FRAX414)
Affinity DataIC50: 559nMAssay Description:Inhibition of PAK4 (unknown origin) in presence of ATP by Z-LYTE enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM6276(Pyrido[2,3-d]pyrimidin-7-one 1 | 8-Cyclopentyl-2-[...)
Affinity DataIC50: 580nMAssay Description:Inhibition of PAK4 (unknown origin) in presence of ATP by Z-LYTE enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 779nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50237830(CHEMBL3799807)
Affinity DataIC50: 790nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Mus musculus)
Genentech

Curated by ChEMBL
LigandPNGBDBM50389109(CHEMBL2064557)
Affinity DataEC50:  810nMAssay Description:Inhibition of PAK4 in mouse NIH3T3 cells assessed as reduction in phosphorylated GEF-H1 accumulation incubated for 30 mins by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652947(CHEMBL5687057)
Affinity DataIC50: 960nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652949(CHEMBL5687001)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to PAK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112353(CHEMBL3609329)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50148931(CHEMBL3770186)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
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