Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50001654
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016991(CHEMBL280055 | 7-Fluoro-2-(4-methoxy-benzyl)-3-met...)
Affinity DataIC50: 7nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 11nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016990(CHEMBL18394 | 2-(4-Methoxy-benzyl)-3,7-dimethyl-5-...)
Affinity DataIC50: 12nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50017001(CHEMBL18946 | 7-Chloro-2-(2,4-dimethoxy-benzyl)-3-...)
Affinity DataIC50: 13nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50017000(CHEMBL278034 | 5-Allyl-7-chloro-2-(4-methoxy-benzy...)
Affinity DataIC50: 20nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016987(CHEMBL18989 | 7-Chloro-2-(4-methoxy-benzyl)-3,5-di...)
Affinity DataIC50: 20nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016998(CHEMBL18694 | 7-Chloro-2-(4-chloro-benzyl)-3-methy...)
Affinity DataIC50: 26nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016994(CHEMBL18820 | 2-Benzyl-7-chloro-3-methyl-5-propyl-...)
Affinity DataIC50: 30nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016985(CHEMBL18050 | 2-(4-Methoxy-benzyl)-3-methyl-5-prop...)
Affinity DataIC50: 31nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 36nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016989(CHEMBL18250 | 7-Chloro-2-(4-methoxy-benzyl)-3,5-di...)
Affinity DataIC50: 46nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016992(CHEMBL18376 | 7-Chloro-5-(3-hydroxy-propyl)-2-(4-m...)
Affinity DataIC50: 76nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM32020(LOX inhibitor, N/A | 4-[4-(3,4-dihydroxyphenyl)-2,...)
Affinity DataIC50: 85nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016997(CHEMBL278507 | 5-tert-Butyl-7-chloro-2-(4-methoxy-...)
Affinity DataIC50: 99nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50017002(CHEMBL18559 | [4-(7-Chloro-4-hydroxy-3-methyl-5-pr...)
Affinity DataIC50: 105nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016991(CHEMBL280055 | 7-Fluoro-2-(4-methoxy-benzyl)-3-met...)
Affinity DataIC50: 129nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016985(CHEMBL18050 | 2-(4-Methoxy-benzyl)-3-methyl-5-prop...)
Affinity DataIC50: 130nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016990(CHEMBL18394 | 2-(4-Methoxy-benzyl)-3,7-dimethyl-5-...)
Affinity DataIC50: 140nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016992(CHEMBL18376 | 7-Chloro-5-(3-hydroxy-propyl)-2-(4-m...)
Affinity DataIC50: 161nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016993(CHEMBL18536 | 7-Chloro-5-ethoxymethyl-2-(4-methoxy...)
Affinity DataIC50: 291nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016999(CHEMBL280281 | 7-Chloro-2-(4-methoxy-benzyl)-3-met...)
Affinity DataIC50: 376nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 400nMAssay Description:Inhibition of 5-lipoxygenase reaction catalyzed by purified enzyme from porcine leukocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016988(CHEMBL18632 | 2-(4-Methoxy-benzyl)-3-methyl-benzof...)
Affinity DataIC50: 574nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016996(CHEMBL280304 | 5,7-Dichloro-2-(4-methoxy-benzyl)-3...)
Affinity DataIC50: 860nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016999(CHEMBL280281 | 7-Chloro-2-(4-methoxy-benzyl)-3-met...)
Affinity DataIC50: 2.00E+3nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016988(CHEMBL18632 | 2-(4-Methoxy-benzyl)-3-methyl-benzof...)
Affinity DataIC50: 2.07E+3nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016995(CHEMBL274233 | 3-[7-Chloro-4-hydroxy-2-(4-methoxy-...)
Affinity DataIC50: 2.13E+3nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50009004(1-Phenyl-pyrazolidin-3-one(phenidone) | 1-phenylpy...)
Affinity DataIC50: 9.20E+3nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity towards soybean lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of partially purified 15-lipoxygenase from human leukocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Pig)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory activity towards porcine 12-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed