Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50044895
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50: 3nMAssay Description:Inhibition of purified PI3Kalpha (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of purified C-Raf (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 12nMAssay Description:Inhibition of purified B-Raf (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50035526(CHEMBL3343621)
Affinity DataIC50: 27nMAssay Description:Inhibition of purified PI3Kalpha (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50035526(CHEMBL3343621)
Affinity DataIC50: 770nMAssay Description:Inhibition of purified mTOR (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50035526(CHEMBL3343621)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of purified FLT3 (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50035526(CHEMBL3343621)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of purified KIT (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50035526(CHEMBL3343621)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of purified C-Raf (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50035526(CHEMBL3343621)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of purified PDGFRbeta (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50035526(CHEMBL3343621)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of purified B-Raf (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50035526(CHEMBL3343621)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of purified EGFR (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50035526(CHEMBL3343621)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of purified VEGFR (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50035526(CHEMBL3343621)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of purified KDR (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed