Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50046262
LigandPNGBDBM31592(PF-2545920 | substituted pyrazole, 9 | US9138494, ...)
Affinity DataIC50: 0.180nMAssay Description:Binding affinity to PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103185(CHEMBL3393194)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103184(CHEMBL3393195)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103183(CHEMBL3393204)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103191(CHEMBL3393199)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103187(CHEMBL3393203)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103193(CHEMBL3393197)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103197(CHEMBL3393190)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103199(CHEMBL3393188)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103188(CHEMBL3393202)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM14754(CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...)
Affinity DataIC50: 36nMAssay Description:Binding affinity to PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50103189(CHEMBL3393201)
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103192(CHEMBL3393198)
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103190(CHEMBL3393200)
Affinity DataIC50: 518nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103196(CHEMBL3393191)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103186(CHEMBL3393207)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103185(CHEMBL3393194)
Affinity DataIC50: 3.07E+3nMAssay Description:Inhibition of human recombinant PDE3A pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103184(CHEMBL3393195)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human recombinant PDE3A pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103185(CHEMBL3393194)
Affinity DataIC50: 4.11E+3nMAssay Description:Inhibition of human recombinant PDE3B pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103198(CHEMBL3393189)
Affinity DataIC50: 4.25E+3nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103184(CHEMBL3393195)
Affinity DataIC50: 6.54E+3nMAssay Description:Inhibition of human recombinant PDE3B pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103194(CHEMBL3393193)
Affinity DataIC50: 6.62E+3nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103185(CHEMBL3393194)
Affinity DataIC50: 7.83E+3nMAssay Description:Inhibition of human recombinant PDE4A pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103185(CHEMBL3393194)
Affinity DataIC50: 8.73E+3nMAssay Description:Inhibition of human recombinant PDE4B pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50103195(CHEMBL3393192)
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103184(CHEMBL3393195)
Affinity DataIC50: 2.54E+4nMAssay Description:Inhibition of human recombinant PDE4A pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103183(CHEMBL3393204)
Affinity DataIC50: 2.59E+4nMAssay Description:Inhibition of human recombinant PDE4B pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103184(CHEMBL3393195)
Affinity DataIC50: 3.06E+4nMAssay Description:Inhibition of human recombinant PDE4B pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103183(CHEMBL3393204)
Affinity DataIC50: 4.03E+4nMAssay Description:Inhibition of human recombinant PDE4A pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103183(CHEMBL3393204)
Affinity DataIC50: 1.67E+5nMAssay Description:Inhibition of human recombinant PDE3A pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50103183(CHEMBL3393204)
Affinity DataIC50: 2.34E+5nMAssay Description:Inhibition of human recombinant PDE3B pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed