Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50045695
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075813(CHEMBL3415598)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075735(CHEMBL3415583)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075740(CHEMBL3415589)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075922(CHEMBL3415606)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075744(CHEMBL3415594)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075747(CHEMBL3415597)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075819(CHEMBL3415604)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075738(CHEMBL3415587)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075732(CHEMBL3414584 | US9775839, 2.1)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075742(CHEMBL3415592)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075730(CHEMBL3415599)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075733(CHEMBL3415610 | US9775839, 8.5)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075743(CHEMBL3415593)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075739(CHEMBL3415588)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075745(CHEMBL3415595)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075821(CHEMBL3415605)
Affinity DataIC50: 1nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075943(CHEMBL3415607)
Affinity DataIC50: 2nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075944(CHEMBL3415609 | US9775839, 3.1)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50011182(CHEMBL3260318)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075741(CHEMBL3415591)
Affinity DataIC50: 5nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075735(CHEMBL3415583)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of GST-fused Zap70 (unknown origin) expressed in insect SF9 cells using biotin-EQEDEPEGDYFEWLE-CONH2 as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075737(CHEMBL3415585)
Affinity DataIC50: 7nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075731(CHEMBL3415608)
Affinity DataIC50: 7nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075736(CHEMBL3415584)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075746(CHEMBL3415596)
Affinity DataIC50: 9nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075734(CHEMBL3415582)
Affinity DataIC50: 19nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075732(CHEMBL3414584 | US9775839, 2.1)
Affinity DataIC50: 30nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075730(CHEMBL3415599)
Affinity DataIC50: 32nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075733(CHEMBL3415610 | US9775839, 8.5)
Affinity DataIC50: 33nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075730(CHEMBL3415599)
Affinity DataIC50: 43nMAssay Description:Inhibition of ROS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075814(CHEMBL3415602)
Affinity DataIC50: 51nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075730(CHEMBL3415599)
Affinity DataIC50: 56nMAssay Description:Inhibition of Syk in anti-IgE-activated human basophils assessed as CysLT release in whole blood preincubated with IL-3 primed blood for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075735(CHEMBL3415583)
Affinity DataIC50: 58nMAssay Description:Inhibition of Syk in anti-IgE-activated human basophils assessed as CysLT release in whole blood preincubated with IL-3 primed blood for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075815(CHEMBL3415603)
Affinity DataIC50: 60nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075733(CHEMBL3415610 | US9775839, 8.5)
Affinity DataIC50: 62nMAssay Description:Inhibition of Syk in anti-IgE-activated human basophils assessed as CysLT release in whole blood preincubated with IL-3 primed blood for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075732(CHEMBL3414584 | US9775839, 2.1)
Affinity DataIC50: 130nMAssay Description:Inhibition of Syk in anti-IgE-activated human basophils assessed as CysLT release in whole blood preincubated with IL-3 primed blood for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075731(CHEMBL3415608)
Affinity DataIC50: 130nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075731(CHEMBL3415608)
Affinity DataIC50: 160nMAssay Description:Inhibition of CHK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075682(CHEMBL3415590)
Affinity DataIC50: 184nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50075681(CHEMBL3415586)
Affinity DataIC50: 371nMAssay Description:Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075731(CHEMBL3415608)
Affinity DataIC50: 420nMAssay Description:Inhibition of TSSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075742(CHEMBL3415592)
Affinity DataIC50: 600nMAssay Description:Inhibition of ERG channel expressed in human embryonic kidney cells assessed as tail current amplitude measured for 3 to 30 mins by PatchXpress elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075744(CHEMBL3415594)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ERG channel expressed in human embryonic kidney cells assessed as tail current amplitude measured for 3 to 30 mins by PatchXpress elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075739(CHEMBL3415588)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of ERG channel expressed in human embryonic kidney cells assessed as tail current amplitude measured for 3 to 30 mins by PatchXpress elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075735(CHEMBL3415583)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of ERG channel expressed in human embryonic kidney cells assessed as tail current amplitude measured for 3 to 30 mins by PatchXpress elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075743(CHEMBL3415593)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of ERG channel expressed in human embryonic kidney cells assessed as tail current amplitude measured for 3 to 30 mins by PatchXpress elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075738(CHEMBL3415587)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of ERG channel expressed in human embryonic kidney cells assessed as tail current amplitude measured for 3 to 30 mins by PatchXpress elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075737(CHEMBL3415585)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of ERG channel expressed in human embryonic kidney cells assessed as tail current amplitude measured for 3 to 30 mins by PatchXpress elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075745(CHEMBL3415595)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of ERG channel expressed in human embryonic kidney cells assessed as tail current amplitude measured for 3 to 30 mins by PatchXpress elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
LigandPNGBDBM50075746(CHEMBL3415596)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of ERG channel expressed in human embryonic kidney cells assessed as tail current amplitude measured for 3 to 30 mins by PatchXpress elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
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