Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50035795
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017434(CHEMBL542293 | 4-{4-[4-(3-trifluoromethylphenyl)he...)
Affinity DataKi:  4nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus and the value ranges from 3 -5More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017437(1,1-Dioxo-2-[4-(2,3,5,6-tetrahydro-[1,2']bipyrazin...)
Affinity DataKi:  9nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus and value ranges from 6 - 13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017432(4-{4-[4-(2-pyrimidinyl)hexahydro-1-pyrazinyl]butyl...)
Affinity DataKi:  10nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-HT1A receptor of rat hippocampus and the value ranges from 9 - 12More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017432(4-{4-[4-(2-pyrimidinyl)hexahydro-1-pyrazinyl]butyl...)
Affinity DataKi:  10nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-HT1A receptor of rat hippocampus and the value ranges from 9 - 12More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50001859(BUSPAR | CHEMBL49 | 8-[4-(4-Pyrimidin-2-yl-piperaz...)
Affinity DataKi:  10nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50005127(1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Affinity DataKi:  10nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017431(CHEMBL552874 | 4-{4-[4-(6-chloro-2-pyrazinyl)hexah...)
Affinity DataKi:  14nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus (94%CI) from 12 to 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017443(3,3-Dioxo-4-{4-[4-(3-trifluoromethyl-phenyl)-piper...)
Affinity DataKi:  15nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus and the value ranges from 12 to 17.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017447(3,3-Dioxo-4-{4-[4-(3-trifluoromethyl-phenyl)-piper...)
Affinity DataKi:  16nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017435(CHEMBL543960 | 4-{4-[4-(2-pyrimidinyl)hexahydro-1-...)
Affinity DataKi:  21nMAssay Description:In vitro ability to inhibit [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus. and the value ranges from 16 - 27More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017442(3,3-Dioxo-4-{4-[4-(3-trifluoromethyl-phenyl)-piper...)
Affinity DataKi:  22nMAssay Description:In vitro ability to inhibit [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus and value ranges from 15 - 31More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017445(4-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-3...)
Affinity DataKi:  34nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus and value ranges from 27 - 42More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017444(4-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-3...)
Affinity DataKi:  45nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus and the value ranges from 25 - 84More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017433(3,3-Dioxo-4-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Affinity DataKi:  53nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus and the value ranges from 48 to 59More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017443(3,3-Dioxo-4-{4-[4-(3-trifluoromethyl-phenyl)-piper...)
Affinity DataKi:  85nMAssay Description:In vitro ability to inhibit [3H]spiperone binding to Dopamine receptor D2 of rat limbic structures and the value ranges from 116 - 159.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50001859(BUSPAR | CHEMBL49 | 8-[4-(4-Pyrimidin-2-yl-piperaz...)
Affinity DataKi:  119nMAssay Description:In vitro ability to inhibit [3H]spiperone binding to dopamine receptor D2 of rat limbic structuresMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017432(4-{4-[4-(2-pyrimidinyl)hexahydro-1-pyrazinyl]butyl...)
Affinity DataKi:  136nMAssay Description:In vitro ability to inhibit [3H]spiperone binding to Dopamine receptor D2 of rat limbic structures and the value ranges from 116 - 159.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017436(3,3-Dioxo-4-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Affinity DataKi:  434nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus and the value ranges from 245 to 736More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017441(CHEMBL543959 | 2-[4-(3'-Chloro-2,3,5,6-tetrahydro-...)
Affinity DataKi:  493nMAssay Description:In vitro ability to inhibit [3H]spiperone binding to Dopamine receptor D2 of rat limbic structures (95%CI) from 375-661More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017440(CHEMBL537242 | 4-[4-(6'-Chloro-2,3,5,6-tetrahydro-...)
Affinity DataKi:  550nMAssay Description:In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus (94%CI) from 391-841More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017431(CHEMBL552874 | 4-{4-[4-(6-chloro-2-pyrazinyl)hexah...)
Affinity DataKi:  1.03E+3nMAssay Description:In vitro ability to inhibit [3H]spiperone binding to Dopamine receptor D2 of rat limbic structures and the value ranges from 116 - 159.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017436(3,3-Dioxo-4-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Affinity DataKi:  1.10E+3nMAssay Description:In vitro ability to inhibit [3H]spiperone binding to Dopamine receptor D2 of rat limbic structuresMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017438(4-{4-[4-(2-pyrimidinyl)hexahydro-1-pyrazinyl]butyl...)
Affinity DataKi:  1.41E+3nMAssay Description:In vitro ability to inhibit [3H]spiperone binding to Dopamine receptor D2 of rat limbic structures and the value ranges from 116 - 159.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017439(3,3-Dioxo-4-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Affinity DataKi:  2.00E+3nMAssay Description:In vitro ability to inhibit [3H]spiperone binding to Dopamine receptor D2 of rat limbic structuresMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50017446(CHEMBL545359 | 4-[4-(3'-Chloro-2,3,5,6-tetrahydro-...)
Affinity DataKi:  3.30E+3nMAssay Description:In vitro ability to inhibit [3H]spiperone binding to Dopamine receptor D2 of rat limbic structures and the value ranges from 116 - 159.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2012
Entry Details Article
PubMed