Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50045878
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50087883(CHEMBL3426930)
Affinity DataKi:  26nMAssay Description:Competitive inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341994(2-(((5-tert-butylthiazol-2-yl)methyl)((4-(4-((4-(h...)
Affinity DataKi:  220nMAssay Description:Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50087881(CHEMBL3426931)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant human PTP1B assessed as hydrolysis of DiFMUP preincubated for 10 mins followed by DiFMUP addition measured after 5 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 318nMAssay Description:Inhibition of human recombinant GST-tagged SHP2 (205 to 593) expressed in Escherichia coli DH5-alpha using DiFMUP as substrate after 30 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 3(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM46223(MLS-0103602.0001 | (4Z)-2-methoxy-4-[piperidin-1-y...)
Affinity DataIC50: 370nMAssay Description:Inhibition of recombinant VHR (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209683((R)-2-(4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thioph...)
Affinity DataIC50: 384nMAssay Description:Inhibition of recombinant human PTP1B (1 to 299) expressed in Escherichia coli using p-nitrophenyl phosphate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50333649((3R,6R)-6-((3S,5R,7R,8R,9S,10S,13R,14S,17R)-3-(3-(...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length PTP1B (unknown origin) after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50342004(4-(2-(3-(4-nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant SHP2 PTP domain (225 to 541) using pNPP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 3(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM31699(MLS000045458 | 4-methoxy-N-[5-(4-methoxyphenyl)-1,...)
Affinity DataIC50: 2.68E+3nMAssay Description:Inhibition of recombinant VHR (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50087880(TAUTOMYCETIN)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of SHP2 catalytic domain (262 to 528) (unknown origin) expressed in Escherichia coli BL21 (DE3) using pNPP as substrate by spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 3(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM82577(N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphe...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of recombinant VHR (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase R(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM82577(N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphe...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of recombinant PTP-SL (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 22(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM82577(N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphe...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of recombinant VHX (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 7(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM82577(N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphe...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of recombinant HePTP (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM82577(N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphe...)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of recombinant LYP (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM82577(N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphe...)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of recombinant TCPTP (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 6(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM82577(N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant MKP3 (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM82577(N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant PTP1B (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 5(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM82577(N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant STEP (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM82577(N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant LAR (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM82577(N-(4-fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant CD45 (unknown origin) using OMFP as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed