Compile Data Set for Download or QSAR
Report error Found 76 Enz. Inhib. hit(s) with all data for entry = 50046088
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094471(CHEMBL3590120)
Affinity DataIC50: 3nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094471(CHEMBL3590120)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 4nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094304(CHEMBL3590118 | US9796700, Compound I-108)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094471(CHEMBL3590120)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094470(CHEMBL3590121)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094312(CHEMBL3590110)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094470(CHEMBL3590121)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094304(CHEMBL3590118 | US9796700, Compound I-108)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094468(CHEMBL3590123)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094468(CHEMBL3590123)
Affinity DataIC50: 13nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094312(CHEMBL3590110)
Affinity DataIC50: 17nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094304(CHEMBL3590118 | US9796700, Compound I-108)
Affinity DataIC50: 19nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094470(CHEMBL3590121)
Affinity DataIC50: 22nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094466(CHEMBL3590125)
Affinity DataIC50: 39nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094306(CHEMBL3590116)
Affinity DataIC50: 40nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094305(CHEMBL3590117)
Affinity DataIC50: 42nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094308(CHEMBL3590114)
Affinity DataIC50: 44nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094466(CHEMBL3590125)
Affinity DataIC50: 47nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094468(CHEMBL3590123)
Affinity DataIC50: 48nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094305(CHEMBL3590117)
Affinity DataIC50: 60nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094466(CHEMBL3590125)
Affinity DataIC50: 66nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094467(CHEMBL3590124)
Affinity DataIC50: 72nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094311(CHEMBL3590111)
Affinity DataIC50: 74nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094469(CHEMBL3590122)
Affinity DataIC50: 77nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094467(CHEMBL3590124)
Affinity DataIC50: 85nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094469(CHEMBL3590122)
Affinity DataIC50: 88nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094467(CHEMBL3590124)
Affinity DataIC50: 90nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094311(CHEMBL3590111)
Affinity DataIC50: 110nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094305(CHEMBL3590117)
Affinity DataIC50: 120nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094312(CHEMBL3590110)
Affinity DataIC50: 120nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50094468(CHEMBL3590123)
Affinity DataIC50: 120nMAssay Description:Inhibition of MEK1 (unknown origin) autophosphorylation incubated with enzyme for 20 mins prior to ATP addition by ADP Glo kinase assay in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094469(CHEMBL3590122)
Affinity DataIC50: 170nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094313(CHEMBL3590109)
Affinity DataIC50: 220nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094313(CHEMBL3590109)
Affinity DataIC50: 240nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094307(CHEMBL3590115)
Affinity DataIC50: 260nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50094466(CHEMBL3590125)
Affinity DataIC50: 260nMAssay Description:Inhibition of MEK1 (unknown origin) autophosphorylation incubated with enzyme for 20 mins prior to ATP addition by ADP Glo kinase assay in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094309(CHEMBL3590113)
Affinity DataIC50: 280nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094308(CHEMBL3590114)
Affinity DataIC50: 340nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094313(CHEMBL3590109)
Affinity DataIC50: 370nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094306(CHEMBL3590116)
Affinity DataIC50: 380nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094311(CHEMBL3590111)
Affinity DataIC50: 380nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094472(CHEMBL3590119)
Affinity DataIC50: 480nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50094313(CHEMBL3590109)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MEK1 (unknown origin) autophosphorylation incubated with enzyme for 20 mins prior to ATP addition by ADP Glo kinase assay in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094314(CHEMBL3590108)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50094309(CHEMBL3590113)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
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