Compile Data Set for Download or QSAR
Report error Found 91 Enz. Inhib. hit(s) with all data for entry = 50046328
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106285(CHEMBL3596279 | US9550771, Example 91)
Affinity DataEC50:  2nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106287(CHEMBL3598148 | US9550771, Example 17)
Affinity DataEC50:  2nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106287(CHEMBL3598148 | US9550771, Example 17)
Affinity DataEC50:  4nMAssay Description:Inverse agonist activity at GAL4-fused human RORc expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106288(CHEMBL3598149 | US9550771, Example 28)
Affinity DataEC50:  9nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106286(CHEMBL3598141 | US9550771, Example 27)
Affinity DataEC50:  10nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106288(CHEMBL3598149 | US9550771, Example 28)
Affinity DataEC50:  10nMAssay Description:Inverse agonist activity at GAL4-fused human RORc expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106286(CHEMBL3598141 | US9550771, Example 27)
Affinity DataEC50:  13nMAssay Description:Inverse agonist activity at GAL4-fused human RORc expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106285(CHEMBL3596279 | US9550771, Example 91)
Affinity DataEC50:  13nMAssay Description:Inverse agonist activity at GAL4-fused human RORc expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106301(CHEMBL3598140)
Affinity DataEC50:  16nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106290(CHEMBL3596276 | US9550771, Example 89)
Affinity DataEC50:  26nMAssay Description:Inverse agonist activity at GAL4-fused human RORc expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106290(CHEMBL3596276 | US9550771, Example 89)
Affinity DataEC50:  27nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106289(CHEMBL3596270 | US9550771, Example 21)
Affinity DataEC50:  32nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106289(CHEMBL3596270 | US9550771, Example 21)
Affinity DataEC50:  36nMAssay Description:Inverse agonist activity at GAL4-fused human RORc expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106302(CHEMBL3598142 | US9550771, Example 22)
Affinity DataEC50:  58nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106296(CHEMBL3596273 | US9550771, Example 69)
Affinity DataEC50:  77nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106324(CHEMBL3598143)
Affinity DataEC50:  84nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106293(CHEMBL3596269 | US9550771, Example 41)
Affinity DataEC50:  97nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106325(CHEMBL3598150 | US9550771, Example 29)
Affinity DataEC50:  100nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106301(CHEMBL3598140)
Affinity DataIC50: 130nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106295(CHEMBL3596272 | US9550771, Example 64)
Affinity DataEC50:  190nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106299(CHEMBL3596277 | US9550771, Example 71)
Affinity DataEC50:  220nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106298(CHEMBL3596275 | US9550771, Example 72)
Affinity DataEC50:  240nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106297(CHEMBL3596274 | US9550771, Example 88)
Affinity DataEC50:  250nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106288(CHEMBL3598149 | US9550771, Example 28)
Affinity DataIC50: 320nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50085045(5-((4-((6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-...)
Affinity DataIC50: 340nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106331(CHEMBL3598151)
Affinity DataEC50:  400nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106292(CHEMBL3598155 | US9550771, Example 92)
Affinity DataEC50:  440nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106326(CHEMBL3598153 | US9550771, Example 30)
Affinity DataEC50:  540nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106287(CHEMBL3598148 | US9550771, Example 17)
Affinity DataIC50: 650nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106300(CHEMBL3596278 | US9550771, Example 79)
Affinity DataEC50:  670nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataIC50: 720nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50106289(CHEMBL3596270 | US9550771, Example 21)
Affinity DataIC50: 760nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106294(CHEMBL3596271 | US9550771, Example 63)
Affinity DataEC50:  840nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106296(CHEMBL3596273 | US9550771, Example 69)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106290(CHEMBL3596276 | US9550771, Example 89)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106286(CHEMBL3598141 | US9550771, Example 27)
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106325(CHEMBL3598150 | US9550771, Example 29)
Affinity DataIC50: 1.80E+3nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106302(CHEMBL3598142 | US9550771, Example 22)
Affinity DataIC50: 2.10E+3nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106327(CHEMBL3598144)
Affinity DataEC50:  2.60E+3nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106295(CHEMBL3596272 | US9550771, Example 64)
Affinity DataIC50: 2.90E+3nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106285(CHEMBL3596279 | US9550771, Example 91)
Affinity DataIC50: 3.40E+3nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106324(CHEMBL3598143)
Affinity DataIC50: 4.20E+3nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106332(CHEMBL3598152)
Affinity DataEC50:  4.30E+3nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106298(CHEMBL3596275 | US9550771, Example 72)
Affinity DataIC50: 5.50E+3nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106294(CHEMBL3596271 | US9550771, Example 63)
Affinity DataIC50: 5.60E+3nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50106291(CHEMBL3598154)
Affinity DataEC50:  6.80E+3nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106297(CHEMBL3596274 | US9550771, Example 88)
Affinity DataIC50: 7.70E+3nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106300(CHEMBL3596278 | US9550771, Example 79)
Affinity DataIC50: 9.10E+3nMAssay Description:Displacement of fluormone PPARgamma green from GST-tagged human PPARgamma-LBD after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106289(CHEMBL3596270 | US9550771, Example 21)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused human PXR expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50106290(CHEMBL3596276 | US9550771, Example 89)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused human PXR expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
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