Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50046607
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50106249([2-(1-Benzenesulfonyl-1H-indol-4-yl)-ethyl]-dimeth...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HeLa cells after 60 mins by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor expressed in HeLa cells after 120 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM34141(CHEMBL76237 | MS-245)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HEK293 cells after 60 mins by liquid scintillation spectromet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50106250([2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-dimeth...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HeLa cells after 60 mins by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor expressed in HeLa cells by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM21354(2-{1-[(5-chlorothiophene-2-)sulfonyl]-1H-indol-3-y...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor expressed in HeLa cells after 120 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataEC50:  7.30nMAssay Description:Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM21366(CHEMBL366151 | (2-{3-[(3-fluorobenzene)sulfonyl]-1...)
Affinity DataKi:  13nMAssay Description:Displacement of radioligand from human 5-HT6 receptor expressed in HeLa cells by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM34142(2-ethyl-5-methoxy-N,N-dimethyltryptamine | EMDT | ...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HEK293 cells after 60 mins by liquid scintillation spectromet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50085970([2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]dimethy...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HEK293 cells after 60 mins by liquid scintillation spectromet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50171234([2-(5-Chloro-2-methyl-1H-indol-3-yl)-ethyl]-dimeth...)
Affinity DataKi:  29nMAssay Description:Displacement of [3H] lysergic acid diethylamide from rat 5-HT6 receptor transfected in HEK293 cells after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50171234([2-(5-Chloro-2-methyl-1H-indol-3-yl)-ethyl]-dimeth...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at 5-HT6 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2B(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50171234([2-(5-Chloro-2-methyl-1H-indol-3-yl)-ethyl]-dimeth...)
Affinity DataKi:  245nMAssay Description:Binding affinity to 5-HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50171234([2-(5-Chloro-2-methyl-1H-indol-3-yl)-ethyl]-dimeth...)
Affinity DataKi:  290nMAssay Description:Binding affinity to 5-HT7 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50171234([2-(5-Chloro-2-methyl-1H-indol-3-yl)-ethyl]-dimeth...)
Affinity DataKi:  300nMAssay Description:Binding affinity to human recombinant alpha2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed