Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50046165
TargetAurora kinase A(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 7nMAssay Description:Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50097413(CHEMBL3586473)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50097413(CHEMBL3586473)
Affinity DataIC50: 18nMAssay Description:Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM31093(cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50097414(CHEMBL3586468)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM31093(cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...)
Affinity DataIC50: 34nMAssay Description:Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50097413(CHEMBL3586473)
Affinity DataIC50: 150nMAssay Description:Binding affinity to GABAA alpha-1 benzodiazepine binding site (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50097414(CHEMBL3586468)
Affinity DataIC50: 170nMAssay Description:Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM31093(cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...)
Affinity DataIC50: 330nMAssay Description:Binding affinity to GABAA alpha-1 benzodiazepine binding site (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 490nMAssay Description:Binding affinity to GABAA alpha-1 benzodiazepine binding site (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of aurora kinase B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50097418(CHEMBL41816)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50097413(CHEMBL3586473)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of aurora kinase B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM31093(cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of aurora kinase B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50097418(CHEMBL41816)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50097418(CHEMBL41816)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora kinase B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50097414(CHEMBL3586468)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora kinase B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataKi:  0.300nMAssay Description:Competitive inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM31093(cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...)
Affinity DataKi:  7nMAssay Description:Competitive inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2016
Entry Details Article
PubMed